Page 1 (data 1 to 30 of 171) | Displayed ini 30 data/page
1 2 3 4 5 6 NEXT >>

1	Biology	ABS-1
Relationship between Class X Students Reading Comprehension Ability and Mastery of Biodiversity Material Using E-Module Listiawati Oktaviani (a*), Adisyahputra (b), Hanum Isfaeni (b) a) Biology Education, Jakarta State University Jl. Rawamangun Muka, RT.11/RW.14, Rawamangun, Pulo Gadung, Kota Jakarta Timur, DKI Jakarta. *listiawati_1312822010[at]mhs.unj.ac.id (b) Faculty of Mathematics and Natural Sciences Abstract Using e-modules can make it easier for students to understand complex concepts in biology, especially biodiversity material. However, the success of e-modules as teaching materials is independent of the design and content but also of the ability of students to understand them individually. Many aspects influence the success of e-modules as a learning tool, one of which is reading comprehension ability. Reading comprehension skills are essential in determining how well they can utilize e-modules. Reading with understanding is sufficient because students need to read, process, and understand the text^s meaning. This research aims to determine the relationship between reading comprehension ability and mastery of biodiversity material using e-modules. This research was conducted in semester II, 2023/2024. The method used in this research is a quantitative descriptive method with correlation studies. The sample was taken from as many as 177 SMAN 12 Tangerang City students. The prerequisite test shows that the data is normally distributed, the data is homogeneous, the data is linear, the data is accessible from symptoms of heteroscedasticity, the data is not multicollinearity, and the data is accessible from symptoms of autocorrelation. Through hypothesis testing, the equation &#374- = 52.954 + 0.475X2 is obtained. The correlation coefficient obtained was 0.573, meaning a moderate relationship exists. Based on this research, it can be concluded that there is a positive relationship between reading comprehension ability and mastery of biodiversity material using e-modules. Keywords: biology, mastery of biodiversity material using e-modules, reading comprehension ability Share Link | Plain Format | Corresponding Author (Listiawati Oktaviani)

2	Biology	ABS-2
Molecular Docking of Red Ginger Beta Pinene Compound in Dense Granules Protein-1 of Toxoplasma gondii Listiawati Oktaviani (a*), Hanum Isfaeni (b) a) Biology Education, Jakarta State University Jl. Rawamangun Muka, RT.11/RW.14, Rawamangun, Pulo Gadung, Kota Jakarta Timur, DKI Jakarta. *listiawati_1312822010[at]mhs.unj.ac.id (b) Faculty of Mathematics and Natural Sciences Abstract Prevention and control of toxoplasmosis involve the use of anti-toxoplasma as one of the treatment methods. Antitoxoplasma is a group of compounds that can kill or inhibit the growth of T. gondii. However, the use of anti-toxoplasma drugs faces several challenges, such as resistance and side effects caused by T. gondii to these drugs. Therefore, in facing these challenges and problems, it is essential to explore new potential chemical compounds that are effective and safe. One approach that can be used is the development of chemical compounds with innovative mechanisms of drug action, such as drugs that interact with protein targets. This research aims to evaluate the activity of the beta-pinene compound contained in red ginger as an anti-toxoplasma agent through interaction with the GRA1 protein using the in silico molecular docking method. This research utilized the three-dimensional structure of the red ginger beta-pinene compound obtained from the PubChem database and the GRA1 protein structure (pdb. ID: P13403). The jam also uses a computer with the Windows 10 64bit operating system and programs such as Autodock, Open Babel, PyRx, and the SWISS model prediction web server application. The molecular docking results between the GRA1 protein and the beta-pinene compound contained in red ginger show a low binding affinity. The binding affinity value of GRA1 and beta-pinene in red ginger is -5.1. This indicates that the beta-pinene contained in red ginger interacts with the active site of the GRA1 protein, so it has potential as an antitoxoplasma candidate. The conclusion obtained from this research is that the beta-pinene contained in red ginger interacts with the active site of the GRA1 protein, so it has the potential as an antitoxoplasma candidate, and the Beta-Pinene ligand forms five hydrophobic interactions. Keywords: molecular docking, red ginger, toxoplasma gondii Share Link | Plain Format | Corresponding Author (Listiawati Oktaviani)

3	Biology	ABS-3
The Relationship Between Knowledge of Ecosystem Concepts Based on Local Wisdom and Ecological Behavior student in SMA 97 Jakarta Sisi Hernanda Pratama (a*), Diana Vivanti Sigit (b), Ratna Komala (b) a,b) Biology Education, Jakarta State University Jalan Rawamangun Muka Raya 11, Jakarta 13220, Indonesia *humas[at]unj.ac.id Abstract Several ecosystems have currently experienced damage due to several factors, both natural and due to human activities. Efforts to minimize this damage can be done by encouraging students to be aware of the natural resources around them, one of which is based on local wisdom. Through ecosystem knowledge based on local wisdom students are expected to have ecological behavior. This research aims to (1) analyze the relationship between knowledge of ecosystem concepts based on local wisdom and ecological behavior, (2) analyze the relationship between knowledge of ecosystem concepts based on local wisdom and ecological behavior . This research uses quantitative descriptive methods. Respondents consisted of 168 students of class X Science at SMAN 97 Negeri Jakarta who were taken using a simple random sampling technique. Data were tested for normality, homogeneity and linearity to be analyzed using multiple regression correlation. The research results show that (1) there is a positive and strong correlation between knowledge of ecosystem concepts based on local wisdom and ecological behavior, (2) there is a simultaneous positive and strong correlation between knowledge ecosystem concept based on local wisdom and ecological behavior. The findings of this research are that consistency is needed in every activity carried out to improve students^ ecological behavior. Keywords: Ecosystem- local wisdom- ecological behavior. Share Link | Plain Format | Corresponding Author (Sisi Hernanda Pratama)

4	Biology	ABS-5
Students Perceptions of the Use of Ecosystem E-Book Learning Media Arrum Ardila Faros (a*), Supriyatin (b), Ratna Komala (b) a,b) Biology Education, Jakarta State University Jalan Rawamangun Muka Raya, 11 Jakarta 13220, Indonesia *humas[at]unj.ac.id Abstract Students receive information through the usage of learning media as a tool or method. Students^ interest and desire in studying can be positively impacted by the use of e-books, resulting in favorable responses. This research aims to determine students^ perceptions of the use of the E-Book Ecosystem as a learning media. This study used a cross-sectional survey with 60 SMA Muhammadiyah 4 Jakarta class X students as the sample. Three dimensions are measured by the instrument, which is a questionnaire: affective, cognitive, and conative dimensions. These dimensions were further expanded into fifteen statement questions. Affective reaction (77.20%), cognitive response (79.80%), and conative response (76.60%) yielded percentage findings for each aspect, with an average of 77.86%. In light of this, it can be said that students responded well to the electronic book, which will enable it to enhance the learning process overall and the material ecosystem in particular. Keywords: E-Book- Ecosystem- Media Share Link | Plain Format | Corresponding Author (Arrum Ardila Faros)

5	Biology	ABS-8
The Relationship Between Scientific Literacy and the Ability to Solve Environmental Pollution Problems (a*) Yunita Ainun Jariah (b) Diana Vivanti Sigit (c) Adisyahputra (abc) Biology Education, Jakarta State University,Jl. R.Mangun Muka Raya No.11, RT.11/RW.14, Rawamangun, Kec. Pulo Gadung, Kota Jakarta Timur, Daerah Khusus Ibukota Jakarta 13220 Abstract The problem of environmental pollution is a challenge for all living things on earth. One effort that can be made to increase environmental awareness is through education. One of the agents who can be involved in overcoming various existing environmental problems is students. In order to support students^ ability to solve environmental pollution, they need to have scientific literacy. This research aims to analyze the relationship between scientific literacy and students^ ability to solve environmental pollution problems. The research method used in this research was a survey method conducted at 2 high schools in the Jakarta area with a total of 197 students. The instruments used are scientific literacy tests and environmental pollution problem-solving ability tests. The results of the research conducted can be concluded that there is a positive correlation between scientific literacy and students^ ability to solve environmental pollution problems. Keywords: Environmental pollution- scientific literacy- learners Share Link | Plain Format | Corresponding Author (Yunita Ainun Jariah)

6	Biology	ABS-10
In Silico Screening for the Potential of Allicin Compound from Allium sativum as an cancer madicine Anisa Minatani (a*), Hanum Isfaeni (b) (a) Universitas Negeri Jakarta Jl. R.Mangun Muka Raya No.11, RT.11/RW.14, Rawamangun, Kec. Pulo Gadung, Kota Jakarta Timur, Daerah Khusus Ibukota Jakarta 13220, Indonesia *minatanianisa[at]gmail.com (b)Biology Education Master Study Program, Faculty Of Mathematics and Sciences, Universitas Negeri Jakarta Abstract The drug discovery process is very complex and requires many stages and takes a long time. Drug design with a structural approach using computational methods can increase the speed of the drug discovery process. The goal of drug design is to find chemical compounds that can interact well with receptors. One method that can be used to design new drugs is molecular docking. The aim of this research is to carry out molecular docking simulations and toxicity tests for the allicin compound as a mitogen-activated protein kinase 8/9/10 (c-jun n-terminal kinase) in cancer. Based on the docking results of the mitogen target protein with the allicin compound, an RMSD value of 0 was obtained and a binding affinity value of -7.3. An RMSD value of 0 indicates that the native ligand conformation resulting from docking is close to the true conformation. Apart from molecular docking, this research also carried out physicochemical analysis, drug similarity, pharmacokinetics and toxicity. Allicin has quite good physicochemical, druglikeness and pharmacokinetic parameters. Keywords: Allicin, Cancer, Allium sativum Share Link | Plain Format | Corresponding Author (Anisa Minatani)

7	Biology	ABS-18
Molecular Docking and Toxicity Test of Turmeric Curcumin Compounds (Curcuma longa) as Beta-Secretase 1 (BACE1) Inhibitors in Alzheimer^s Disease Pretty Nurwhite Tika (a*), Hanum Isfaeni (b) a) Master of Biology Education, Jakarta State University, Jl. R.Mangun Muka Raya No.11, Jakarta 13220, Indonesia *prettynt14[at]gmail.com b) Master of Biology Education, Jakarta State University, Jl. R.Mangun Muka Raya No.11, Jakarta 13220, Indonesia Abstract The drug discovery process is very complex, requiring many steps and a long time. Drug design with a structural approach using computational methods can increase the speed of the drug discovery process. The goal of drug design is to find chemical compounds that can interact well with receptors. One of the methods that can be used to design new drugs is molecular docking. The purpose of this study is to conduct molecular docking simulations and toxicity tests of the turmeric curcumin compound (Curcuma longa) as a beta-secretase 1 (BACE1) inhibitor in Alzheimer^s disease. Based on the docking result of the BACE1 target protein with the curcumin compound, an RMSD value of 0 and a binding affinity value of -7.3 were obtained. An RMSD value of 0 indicates that the native ligand conformation of docking results is close to the real conformation. In addition to molecular docking, this study also conducted physicochemical analysis, drug similarity/druglikeness, pharmacokinetics, and toxicity. Curcumin has good physicochemical parameters, druglikeness, and pharmacokinetics. However, based on the results of the toxicity analysis, this curcumin compound has immunotoxic potential, so further research is needed regarding the use of curcumin as a drug candidate. Keywords: Curcumin, BACE1, Alzheimer^s, Molecular Docking Share Link | Plain Format | Corresponding Author (Pretty Nurwhite Tika)

8	Biology	ABS-20
Application of digital comics to improve students^ critical thinking skills Shania Putri Apriani (a*), Sekar Darmastuti (a), Anis Fitri Wahyuni (a) (a*)Magister of Biology Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Jakarta-Indonesia shania123.spa[at]gmail.com Abstract Critical Thinking Skills are one of the skills needed in the 21st century in developing education in Indonesia which is increasingly complex so it needs to be trained in schools. So the teacher^s efforts to improve the development of students^ critical thinking skills in the learning process include using learning media in the form of digital comics to obtain maximum learning results in biology material which is considered quite difficult, especially bacterial material, for around 85.7% of students. This research uses a quasi-experimental method with a pre-test and post-test one-group design treatment design. The research hypothesis uses the dependent t-test. They are measuring critical thinking skills using 17 multiple-choice questions with reasons. Based on data analysis, the average pre-test score was 36.40. The average post-test score was 53.09. The t-test results show a significant value of 0.00 < &#945- = 0.05 and a calculated t-value < t-table of -20.913 <1.691, which means the difference is statistically significant or significant at a probability of 0.05. Thus, it can be concluded that there is an influence of using digital comic learning media on bacterial material to improve students^ critical thinking skills. Keywords: Critical thinking, Bacterial, Digital Comics Share Link | Plain Format | Corresponding Author (shania putri apriani)

9	Biology	ABS-21
Blended Learning Flipped Classroom (BLFC) VS Problem-Based Learning on Students Critical Thinking Skills in Animalia Material Sekar Darmastuti (a*), Nurmasari Sartono (a), Hanum Isfaeni (a) a) Magister of Biology Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Jakarta-Indonesia *sekardarmastuti[at]gmail.com Abstract In the era of globalization, information can develop very quickly. Thinking skills are needed to support someone in facing these changes. One of these thinking skills is critical thinking skills, and for that, this skill needs to be trained and improved. Learning models that can improve these skills are blended learning flipped classroom (BLFC) and problem-based learning. Therefore, this study was conducted to compare students critical thinking skills between classes that implement BLFC and classes that implement problem-based learning on animalia material. This study used a quasi-experimental method with a post-test-only treatment design. The research hypothesis testing used an independent t-test. Then, to measure students critical thinking skills, 25 multiple-choice questions were used with reasons. Based on the study results, it can be concluded that there is a difference in critical thinking skills between classes that implement BLFC and problem-based learning classes. This difference can be seen in the average value of students critical thinking skills in the BLFC class being higher. This happens because the BLFC class is facilitated with online classes that can be used as a discussion space and sharing learning materials. Keywords: Flipped Classroom- Blended Learning- Critical Thinking Share Link | Plain Format | Corresponding Author (Sekar Darmastuti)

10	Biology	ABS-23
APPLICATION OF STEM-BASED DISCOVERY LEARNING MODEL TO IMPROVE MARINE LITERACY Uswatun Khasanah Arifin(a*), Supriyatin (b), Hanum Isfaeni(b) a Biology Education Study Program, Postgraduate School, Jakarta State University, Jl. Rawamangun Muka Raya No.11, Kota Jakarta Timur 13220, Indonesia *uswatunkhasanaharifin[at]gmail.com b Department of Biology Education, Faculty of Mathematics and Natural Sciences Education, State University of Jakarta, Jakarta Timur 13220, Indonesia Abstract Indonesia is known as a maritime country, one of which is the Indramayu area located in West Java. Students do not know much about issues surrounding marine pollution in the Indramayu area, so an understanding of marine literacy is needed. The application of the STEM-based discovery learning model for students is a scientific learning process that provides students with the opportunity to identify problems that are relevant to the real world and involve various STEM disciplines. The study aims to improve marine literacy through the application of the STEM-based discovery learning model. The research method used in this study is Quasi-Experimental, the research design is Nonequivalent Control Group Design. The research subjects used were class X students of MAN in Indramayu, West Java, who studied coastal ecosystems in the 2023/2024 academic year. The sample of participants in this study was 60 students. The research instrument used was an essay of 8 questions based on the 7 principles of marine literacy referring to SOLE (survey of ocean literacy and experience) which had been modified by the researcher. Based on the research results, it can be concluded that MAN students^ marine literacy on ecosystem material is still in the low category in the second principle of 39%, the sixth principle of 48%, because biology subjects have not been integrated with marine subjects. Keywords: Marine literacy, STEM-based discovery learning, coastal ecosystem, local potential Share Link | Plain Format | Corresponding Author (uswatun khasanah arifin)

11	Biology	ABS-26
BARBALOIN COMPOUND ONE OF THE COMPONENTS OF THE Aloe Vera Plant Leaves (ALOE VERA) AS A LAXATIVE (LAXATIVE) Annisa Jamilatussholihah Qurrota Ainin (a*), Hanum Isfaeni (b) a) Master of Biology Education, Universitas Negeri Jakarta Jalan Rawamangun Muka Raya No.11, Kota Jakarta Timur, Daerah Khusus Ibukota Jakarta 13220 *annisajamilatus[at]gmail.com b) Master of Biology Education, Universitas Negeri Jakarta Jalan Rawamangun Muka Raya No.11, Kota Jakarta Timur, Daerah Khusus Ibukota Jakarta 13220 Abstract Aloe vera (Aloe vera) has a water content of up to 98-99%, the rest is 75 active compounds which have been proven to have potential as antioxidants. Aloe vera (Aloe vera) contains the compound barbaloin and essential amino acids. Which has a laxative (laxative) effect due to its content. The results of molecular docking showed that there was an interaction between Aloe vera and the barbaloin compound with a binding affinity of - 7.7. If the results were very negative, it was certain that the natural compound was a good compound. In the visualization that focuses on the 2D Post View ligand, a diagram is obtained depicting the interaction between the ligand (barbaloin) and the target protein and also the hydrogen bonds, hydrophobic bonds and amino acid residues of the target protein. It has been proven that barbaloin is useful as a laxative, so in the pharmaceutical world aloe vera has a very important role because of its barbaloin content. Keywords: Aloe vera- barbaloin compound- laxative Share Link | Plain Format | Corresponding Author (Annisa Jamilatussholihah Qurrota Aninin)

12	Biology	ABS-27
Apoptosis in Spirulina platensis as an anti-breast cancer compound (Antineoplastic) Dwi Fitriany Hanafi (a*), Hanum Isfaeni (b) a) Master of Biology Education, Universitas Negeri Jakarta Jalan Rawamangun Muka Raya No.11, Kota Jakarta Timur, Daerah Khusus Ibukota Jakarta 13220 *dwihanafi660[at]gmail.com b) Master of Biology Education, Universitas Negeri Jakarta Jalan Rawamangun Muka Raya No.11, Kota Jakarta Timur, Daerah Khusus Ibukota Jakarta 13220 Abstract The problem of cancer in Indonesia is recorded every year as many as 100 new cases occur among 100,000 residents. Sufferers of this disease were found to be in an advanced stage. The search for new drug sources to produce anticancer compounds from various sources continues. One source that can be used is marine biota. Spirulina platensis algae is a type of microalgae that is a rich source of nutrients and its extract has potential as an antioxidant, antimicrobial, antiviral, anti-inflammatory and antitumor. In fact, several reports note that chlorophyll a derivatives also have potential as antimutagens, apoptosis inductors and photosensitizers for PDT (Photodynamic Cancer Therapy). Spirulina plantesis with apoptotic compounds as anti-cancer (Antineoplastic) with a binding affinity result of -7.4, if the results are very negative, then it is certain that the natural compound is a good compound. In the visualization that focuses on the Post View 2D ligand, a diagram is obtained that depicts the interaction between the ligand (Apoptosis) and the target protein and also obtains the hydrogen bonds, hydrophobic bonds and amino acid residues of the target protein. It has been proven that apoptosis is useful as an anti-cancer compound. Keywords: Apoptosis- Spirulina Plantesis- Antineoplastic Share Link | Plain Format | Corresponding Author (Dwi Fitriany Hanafi)

13	Biology	ABS-29
How Will Knowledge Contributes to Self-Health Awareness of Sexual Transmitted Disease (STD)?: Analysis on High School Student Daffa Azalia1 (a*), Refirman Djamahar1 (b), Sri Rahayu2 (b) 1Biology Education, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta 2Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta Abstract Sexually Transmitted Diseases (STDs) are diseases that require special attention due to the increasing prevalence of STDs, many of which are asymptomatic. Adolescents are one of the vulnerable groups to STDs because of high curiosity but limited access to reproductive health knowledge from teachers or formal education. To change the lack of knowledge about STDs, it can be started from the students health awareness as self-awareness is one of the life skills that can affect adolescents in making decisions to prevent STDs. This research aims to determine the relationship between STDs knowledge and self-health awareness of high school students. This research was carried out from January 2023 at SMA Negeri 29 Jakarta. The method used descriptive quantitative through correlational study approach. A sample of 108 people was determined by simple random sampling. Students STDs knowledge was measured using tests, and self-health awareness by questionnaires. The results of the pre-requisite test results indicated normal and homogeneous data. The calculated correlation coefficient was 0,620 that indicating a strong category correlation. Knowledge of STDs contributing of 38,4% to the student self-health awareness. This research concludes that there is a positive relationship between STDs knowledge and self-health awareness of high school students. Keywords: High School Student, Knowledge, Self-Health Awareness, Sexual Transmitted Disease Share Link | Plain Format | Corresponding Author (Daffa Azalia)

14	Biology	ABS-31
INTERACTIVE E-BOOKLETS AS DIGITAL LEARNING MEDIA INNOVATION TO FACILITATE 21ST CENTURY LEARNING Syifa Faridatun Nisa Jakarta State University Abstract 21st century learning requires innovative and interactive digital learning media to support the various competencies that students must have. Lack of innovation in the utilization of technology in learning can cause students to be unable to achieve learning objectives. Digital learning media has developed rapidly and has high potential in supporting the learning process. One of the learning media that is in accordance with the development of digital technology is an interactive e-booklet. The purpose of this research is to identify the needs in developing digital learning media in the form of interactive e-booklets. The type of research used is qualitative research. Data collection techniques through observation and questionnaire. The results showed that the learning media used in schools are material power points (79.5%), learning videos (28.2%), 2D images (23.1%), and torsos (5.1%). A total of 74.4% of students agreed to use interactive e-booklet media. The results of this study can be the basis for teachers to create and implement digital learning media in the form of interactive e-booklets to facilitate 21st century learning. Keywords: INTERACTIVE E-BOOKLETS, DIGITAL LEARNING MEDIA, 21ST CENTURY LEARNING Share Link | Plain Format | Corresponding Author (Syifa Faridatun Nisa)

15	Biology	ABS-32
Identification of Ascorbic-acid Compounds in Moringa Leaves (Moringa oleifera L.) as Anti- Inflammatories through Ligands in the Toll-Like Receptor Signaling Pathway for In Silico Prediction of Stunting Prevention Henny Iriantini (a*), Hanum Isfaeni (b) a) Master of Biology Education, Faculty of Mathematics and Natural Sciences, State University of Jakarta. Jl. Rawamangun Muka Raya No. 11, RT 11/RW. 14, East Jakarta 13220, DKI Jakarta, Indonesia. *hennyiriantini639[at]gmail.com b) State University of Jakarta. Jl. Rawamangun Muka Raya No. 11, RT 11/RW. 14, East Jakarta 13220, DKI Jakarta, Indonesia. Abstract Stunting is a condition of chronic malnutrition in toddlers. In the pathophysiology of stunting, inflammation plays an important role by inducing growth hormone (GH) resistance, increasing the body^s nutritional needs and anemia. Moringa leaves (Moringa oleifera) are useful in curing 24 chronic metabolic diseases including stunting. The aim of this study was to identify the bioactive compound Moringa oleifera as an anti-inflammatory through its ligands in the Toll-like receptor signaling pathway for the prediction of stunting prevention in silico. This research method is descriptive exploratory using Dr.^s online database. Duke^s Phytochemical and Ethnobotanical Databases, PubChem, PASS Online, SEA, SwissTargetPrediction, and STRING. The results showed that the moringa plant has 6 bioactive compounds that have potential as anti inflammatories, namely ascorbicacid, beta-carotene, caffeic-acid, kaempferol, quercetin, tocopherol. Screening of target protein network construction obtained an anti-inflammatory signaling pathway through the KEGG pathway Tolllike receptor signaling pathway and there are 9 target proteins that play a role in the signaling pathway, namely NF-kappa-B essential modulator (IKBKG). Keywords: Ascorbic-acid Moringa oleifera L., anti imflammatory ligand, stunting in silico Share Link | Plain Format | Corresponding Author (Henny Iriantini)

16	Biology	ABS-33
Analysis Of Andrographolide Compound From Sambiloto Plant (Andrographis Paniculata Nees) On Alpha Glucosidase As Type II Antidiabetes Ieva Farisna (a*), Hanum Isfaeni (b) a) Master of Biology Education, Faculty of Mathematics and Natural Sciences, State University of Jakarta. Jl. Rawamangun Muka Raya No. 11, RT 11/RW. 14, East Jakarta 13220, DKI Jakarta, Indonesia. *evafarisna24[at]gmail.com b) State University of Jakarta. Jl. Rawamangun Muka Raya No. 11, RT 11/RW. 14, East Jakarta 13220, DKI Jakarta, Indonesia. Abstract The bitter plant contains the Andrographolide compound which can bind to the Alpha Glucosidase protein which can be analyzed by molecular docking using various websites and applications including pubchem, pass online, pharmMapper, swiss targetprediction, string db, swiss-model, fasta, Saveswebserve, pyrix PyMOL, protein plus, swissadme and protox II. The purpose of this analysis is to determine whether the Andrographolide compound is present with the target protein, namely alpha glucosidase, as a type II antidiabetic. Based on the results of this analysis, it was found that there was a hydrophobic bond and there was Met122A which indicated the target protein. This interaction indicates that andrographolide can inhibit alpha glucosidase so that not all oligosaccharides or polysaccharides can be broken down into monosaccharides, so it can prevent and stop the development of type II diabetes with a binding affinity result of -7.6 kcal/mol, this indicates that the more negative the binding affinity results, the natural compound. is the best compound. However, the toxicity level obtained was LD50: 1890mg/kg body weight. Based on the analysis results, it was found that the Andrographolide compound was included in class 4 with LD50: 1890mg/kg, meaning it was dangerous if swallowed because it was hydrophobic and difficult to dissolve in water. Keywords: Andrographolide Compound, Alpha Glucosidase, Sambiloto Plant, Type II Antidiabetes Share Link | Plain Format | Corresponding Author (ieva farisna)

17	Biology	ABS-38
Correlation between Anti-S1 RBD IgG Titer and neutralizing antibodies against SARS-CoV-2 After Heterologous booster immunization Ulfi Rahma Efrianti (a), Beti Ernawati Dewi (b,c*), Tjahjani Mirawati Sudiro (c) a) Master^s Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia b) Infectious Disease and Immunology Cluster, Indonesian Medical Education and Research Institute, Indonesia c) Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital Abstract Antibodies produced by plasma cells in response to the COVID-19 vaccine can be neutralizing and non-neutralizing antibodies. Neutralizing antibodies (nAbs) are important for protection against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. The gold standard for measuring levels of neutralizing antibodies via Plaque Reduction Neutralization Test (PRNT) requiring live pathogen and a Biosafety Level 3 (BSL3) facilities. This study aimed to determine the correlation between Anti-S1 RBD IgG titer and nAbs SARS-CoV-2 in vaccinated subjects. A cross-sectional study was conducted in 20 plasma samples immunized with a primary series of two doses and 36 plasma samples from individuals after booster vaccination (third dose). Anti-S1 RBD IgG titer were determined using indirect ELISA assay. Measure the %inhibition of neutralizing antibody measured by sVNT. The relationship between the Anti-S1 RBD IgG and Neutralizing antibodies were analyzed using Spearman^s correlation coefficient. IgG anti-S1 RBD titer and nAbs decreased with time in a similar pattern. At 24-28 weeks after the 2nd vaccination showed a 60% decrease in antibody titers and a 40% reduction in nAbs. Through Spearman^s correlation, we found correlations between IgG Anti-S1 RBD and the percentage of inhibition of nAbs, after 2nd vaccination (r = 0.720, p-value < 0.0001) and after 3rd vaccination (r = 0.821, p-value < 0.0001) Keywords: SARS-CoV-2- COVID-19- antibody- neutralization- correlation Share Link | Plain Format | Corresponding Author (Ulfi Rahma Efrianti)

18	Biology	ABS-56
The Relationship Between Nutritional Knowledge and Food Choice Attitudes on Post COVID-19 Pandemic among High School Adolescents Saidah Linaili Rahmah, Yulilina Retno Dewahrani, Sri Rahayu Faculty of Mathematics and Natural Sciences, Jakarta State University Abstract Knowledge of nutrients is essential for adolescents to maintain optimal body function and prevent various health issues. The nutritional knowledge taught to high school students plays a crucial role in empowering them to make informed decisions about their health, including their attitudes toward food choices. This study aims to determine the relationship between nutritional knowledge and food choice attitudes among high school adolescents after the COVID-19 pandemic. The research method used is descriptive-correlational, with nutritional knowledge as the independent variable and food choice attitudes as the dependent variable. A sample of 80 students was selected using purposive sampling, followed by simple random sampling. Nutritional knowledge was measured using a multiple-choice test, and food choice attitudes were assessed using the Food Choice Questionnaire (FCQ). Prerequisite test results indicated that the data were normally distributed and homogeneous. The Pearson Product Moment yielded a correlation coefficient of 0.446, indicating a moderate correlation. Nutritional knowledge contributed 19.89% to food choice attitudes. From this study, it can be concluded that there is a positive relationship between nutritional knowledge and food choice attitudes. Keywords: food choice questionnaire, nutritional education, nutritional status of adolescents Share Link | Plain Format | Corresponding Author (Saidah Linaili Rahmah)

19	Biology	ABS-58
The Relationship between Nutritional Knowledge and Food Attitudes on Post COVID-19 Pandemic among High School Adolescents Yulilina Retno Dewahrani (a*), Saidah Linalli Rahmah (a), Sri Rahayu (b) a) Biology Education Department of Faculty of Mathematics and Natural Sciences of Universitas Negeri Jakarta *)yulilinaretno[at]yahoo.co.id b) Biology Department of Faculty of Mathematics and Natural Sciences of Universitas Negeri Jakarta Abstract Knowledge of nutrients is essential for adolescents to maintain optimal body function and prevent various health issues. The nutritional knowledge taught to high school students plays a crucial role in empowering high school students to make informed decisions about their health including food choice attitudes. This study aims to determine the relationship between nutritional knowledge and food choice attitudes on post-COVID-19 pandemic among high school adolescents. The research method used is descriptive-correlational, with nutritional knowledge as the independent variable and food choice attitudes as the dependent variable. 80 sample was conducted using purposive sampling continued by simple random sampling. Nutritional knowledge was measured using a multiple-choice test, and food choice attitudes were assessed using the Food Choice Questionnaire (FCQ). Prerequisite test results indicated that the data were normally distributed and homogeneous. The Pearson Product Moment obtained a result of correlation coefficient is 0.446, indicating a moderate correlation. Nutritional knowledge contributed 19.89% to food choice attitudes. From this study, it can be concluded that there is a positive relationship between nutritional knowledge and food choice attitudes. Keywords: Food choice questionnaire, nutritional education, nutritional status of adolescents Share Link | Plain Format | Corresponding Author (Yulilina Retno Dewahrani)

20	Biology	ABS-59
Comparison of the Reading, Identifying, Constructing, Solving, Reviewing, and Extending (RICOSRE) Model with Discovery Learning on Biology Literacy in Blood Circulation System Material Niken Ivanesya Tarigan (a), Yulilina Retno Dewahrani (a*), Rusdi (a) a) Biology Education Department of Faculty Mathematics and Natural Sciences of Universitas Negeri Jakarta *)yulilinaretno[at]yahoo.co.id Abstract The era of Society 5.0, taking place in the 21st century, brings new challenges related to digital innovation. This emphasizes the use of technology during learning and requires students to possess multiple skills, one of which is biological literacy. Learning models to enhance biological literacy skills include the Reading, Identifying, Constructing, Solving, Reviewing, and Extending (RICOSRE) model and the discovery learning model. The research aim was to determine the differences between the RICOSRE learning model and the discovery learning model on students^ biological literacy skills in the Blood Circulation System material. The study was conducted in the even semester of 2023/2024 at SMA Negeri 30 Jakarta. The research method used was quasi- experimental with a non-equivalent pretest-posttest group design. The research sample consisted of 72 students, with 36 students in each class, selected through purposive sampling. Based on the average calculation results, the scores in the experimental class taught using the Reading, Identifying, Constructing, Solving, Reviewing, and Extending (RICOSRE) learning model were better compared to the class taught using the discovery learning model. The independent t-test results showed that there was a significant difference in biological literacy skills on the Blood Circulation System material between the class implementing the Reading, Identifying, Constructing, Solving, Reviewing, and Extending (RICOSRE) learning model and the class implementing the discovery learning model. The RICOSRE learning model emphasizes reading activities that provide a strong knowledge foundation before students engage in investigation. Keywords: RICOSRE learning model, discovery learning model, biological literacy skills, blood circulation system Share Link | Plain Format | Corresponding Author (Yulilina Retno Dewahrani)

21	Biology	ABS-62
Prototype: E-Learning 21st Century Learning Models with the DARP (Discuss, Archive, Reflect, and Prepare) Approach Eva Nurul Malahayati (a*), Ida Putriani (a), Marinda Sari Sofiyana (a) (a) Faculty of Teacher Training and Education, Balitar Islamic University Jalan Majapahit 4, Kota Blitar 66137, Indonesia *malahayatieva488[at]gmail.com Abstract In the age of digital education, there is a critical need for a learning platform that supports the development of 21st-century skills. The development of an e-learning prototype for 21st-century learning models using the DARP approach was designed to answer these challenges by integrating discussion, archiving, reflection, and preparation activities in an e-learning platform dynamically and collaboratively. The prototype was developed using the System Development Life Cycle (SDLC), which includes planning, analysis, design, implementation, and testing stages. The resulting prototype was tested on a limited scale with lecturers and students to evaluate its functionality, user acceptability, and effectiveness in supporting the learning process. Data collected through a questionnaire was analyzed descriptively. The trial results show that the e-learning prototype for 21st-century learning models using the DARP approach can increase student involvement in discussions, strengthen reflective abilities, and help plan more structured learning. In conclusion, the e-learning prototype using the DARP approach shows potential for further development in supporting the development of 21st-century skills and dynamic learning. Keywords: Prototype Development- E-Learning- DARP Aprroach Share Link | Plain Format | Corresponding Author (Eva Nurul Malahayati)

22	Biology	ABS-67
The Effect of Maggot Flour (Hermetia illucens) on the Growth of Sangkuriang Catfish (Clarias gariepinus) Rusdi,1 Yulilina Retno Dewahrani,1 Tiara Putri Chaerunnisa,1 Bunga Ainindya Balqis,1 Rahma Novianti,1 Nur Novita,1 Melta Rini Fahmi,2 Naufal Ma^arif3 1Department of Biology Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Indonesia 2Agency for Marine and Fisheries Research and Development 3Indonesian Bioinformatics Institute (INBIO-Indonesia) Abstract The public^s need for catfish consumption increases every year. To increase catfish production, good quality feed is needed that meets nutritional needs and stimulates catfish production. Catfish can grow well if their nutritional intake is adequate, especially protein requirements. However, fish feed that is high in protein is often difficult to find, so other alternative feeds are needed to meet protein needs. This research was conducted to determine the effect of feeding with a mixture of maggot flour (Hermetia illucens) on the growth of sangkuriang catfish (Clarias gariepinus). This research used an experimental method with a randomized block design consisting of 4 treatments, namely: A. 0% maggot flour, B. 70% pellets + 30% maggot flour, C. 60% pellets + 40% maggot flour, and D. 50% pellets + 50% maggot flour. Data were analysed using a one-way ANOVA test. The statistical analysis showed that: 1. feeding maggot flour had a significant effect on the growth of catfish (p < 0.05), 2. there is an effect of maggot flour on the length of catfish (p < 0.05). Measuring the protein content in catfish and maggot meat, it was found that the highest average protein content was in the 30% maggot treatment, namely 15.84 mg/mL, while the lowest protein content was in the 50% maggot treatment with an average protein content of 12 .54 mg/mL. From the results of this research, it was also found that the average protein content in maggots was 60.38 mg/mL, which was far above catfish protein. Keywords: catfish, growth, protein maggot Share Link | Plain Format | Corresponding Author (Rusdi Rusdi)

23	Biology	ABS-76
Phytochemical profiles of Persea fruticosa extracts and its antimicrobial potential Tayal Punitha Ramasamy Naidu, Dr Norazah Binti Basar, Dr Syazwani Itri Binti Amran University Technology Malaysia, Malaysia Abstract Antimicrobial resistance (AMR) is one of the top 10 global public health threats faced by humanity. Overuse and not being compliant in antibiotic consumption, led to the growth of drug-resistant pathogens. Medicinal plants have a continuous attraction for an effective antimicrobial agent against resistant pathogens despite the conventional drugs available for infection. Persea americana has been studied widely. But there is very limited study on Persea fruticosa species. This study will be focusing on the identification of phytomedicinal compounds of Persea fruticosa. The antimicrobial activity was tested in vitro. Qualitative analysis of the leaves of Persea fruticosa through thin layer chromatography (TLC) analysis on the petrol ether, ethyl acetate, and methanol extracts revealed the presence of a diverse range of bioactive compounds, including flavonoids and terpenoids. In order to emphasize on polar compounds, methanol extract was subjected to LC -MS analysis, which resulted with ketone, alkaloids, alcohol and amino acids. The affinity of these compounds against four target proteins, Gyrase B, Penicillin binding protein, D alanine and Dihydrofolate were assessed using molecular docking approach. Among the tested compounds, fluoren-9-one demonstrated highest binding affinity ranged from -6.7 to -7.8 kcal/mol towards all proteins. This leads to exploration of the mechanism of action of Persea fruticosa as antibacterial agent. This docking data will be further tested by microbiology testing on several bacteria. This integrative approach combining experimental and computational techniques will provide a comprehensive understanding of the extracts^ antimicrobial potential. This provides promising solution for antimicrobial resistance and minimizing the over usage of antibiotics. Keywords: Antimicrobial resistance (AMR), antimicrobial activity, Persea fruticosa, in vitro and in silico Share Link | Plain Format | Corresponding Author (Tayal Punitha Ramasamy Naidu)

24	Biology	ABS-80
Identification and Prevalence of Parasite Types in Various Freshwater Ornamental Fish in Jakarta Rusdi1, Lulu Friska SalsaBilla1, Rahmadiva Pradesti1, Renata Martanto1, Fitria Pusparini1 Devi Vianika Sri Ambarwati2 and Fathi Alauddin Sulthan2 &#12310-1.&#12311-_(Department of Biology Education,Faculty of Mathematics and Sciences, Universitas Negeri Jakarta) &#12310-2.&#12311-_(Fish Quarantine Quality Control and Fishery Product Safety Jakarta II) Abstract ABSTRACT Freshwater ornamental fish are one of the fishery commodities with economic value. Freshwater ornamental fish have high prices, thereby fish farmer can open business opportunities that quite profitable. Therefore, it is necessary to maintain the health of the fish. This study aimed to identify parasites and measure the prevalence of infection of freshwater ornamental fish in Jakarta. The research was conducted at the Animal Physiology Laboratory of Universitas Negeri Jakarta and the Laboratory of Fish Quarantine Quality Control and Fishery Product Safety Jakarta II. The samples consisted of black tetra (Gymnocorymbus ternetzi), koi (Cyprinus rubrofuscus), goldfish (Carassius auratus), manfish/angelfish (Pterophyllum scalare), and patin (Pangasianodon hypophthalmus) obtained through simple random sampling from the Jatinegara market and the Laboratory of Fish Quarantine Quality Control and Fishery Product Safety Jakarta II. Twenty samples were taken from each fish species, totaling 100 freshwater ornamental fish. The study identified parasites in the freshwater ornamental fish, including Dactylogyrus sp., Gyrodactylus sp., and Trichodina sp. The highest prevalence of Dactylogyrus sp. was found in koi and angelfish, with a prevalence rate of 65%. The highest prevalence of Gyrodactylus sp. was found in koi (Cyprinus rubrofuscus) with a prevalence rate of 15%. The highest prevalence of Trichodina sp. was found in goldfish with a prevalence rate of 45%. Therefore, this study shows that freshwater ornamental fish have identifiable parasites with varying prevalence rates. Keywords: Dactylogyrus sp., Freshwater ornamental fish, Fish parasites, Gyrodactylus sp., Prevalence, Trichodina sp. Share Link | Plain Format | Corresponding Author (Rusdi Rusdi)

25	Biology	ABS-82
The Influence of Feed Types on the Growth and Survival of Comet Fish (Carassius auratus) at Balai Riset Budidaya Ikan Hias (BRBIH) Depok, West Java Rusdi1, Azmy Hani Abidin1 Nabilla Putri Adisty1 Farhan Ananda Pratama1 Joni Haryadi2 Nina Meiliza2 Daniar Setyo Rini1 1Biology Education Major, Faculties of Mathematics and Natural Science, Universitas Negeri Jakarta, l. R.Mangun Muka Raya No.11, RT.11/RW.14, Rawamangun, Kec. Pulo Gadung, Kota Jakarta Timur, Daerah Khusus Ibukota Jakarta 13220 2Balai Riset Budidaya Ikan Hias, KKP, Jl. Perikanan Raya No.13, Pancoran MAS, Kec. Pancoran Mas, Kota Depok, Jawa Barat 16436 *Corresponding author. Tel.: +00-0000-0000- Email address: rusdi[at]unj.ac.id Abstract Feeding is closely related to the growth and survival of fish. Different types of feed will result in different outcomes. The comet fish (Carassius auratus), being one of the most popular ornamental fish, has led to the rise of many comet fish farming businesses. This research aims to determine the most efficient type of feed in comet fish farming by providing three different types of feed to the ornamental comet fish. The experimental design used in this study is the simple random sampling technique, consisting of 3 treatments with 3 repetitions. The research was conducted for 35 days after the fry was 1 month old. The treatments used were commercial fengli feed, bloodworms, and maggot granules. The study^s results showed that bloodworm feeding had a significant effect on the absolute length, daily length growth rate, feed conversion ratio, survival rate, and total feed consumption. The daily growth rate with bloodworms reached 2.09%, better than commercial feed (1.09%) and maggots (1.74%). In terms of daily weight growth rate, the highest percentage was achieved by bloodworms at 5.23%. Bloodworms are easier to consume because they are the right size for comet fish fry. Additionally, bloodworms contain fresher protein, which is better than maggots and commercial feed, ranging from 40-50%. Bloodworms are also beneficial for maximizing the fish^s color quality, as they contain carotenoids. Keywords: Bloodworms, feed conversion ratio, fengli feed, growth performance, maggot granules, survival rate Share Link | Plain Format | Corresponding Author (Rusdi Rusdi)

26	Biology	ABS-83
Description of Data on Screening Results for Infections Infectious Through Blood Transfusion (IMLTD) at Unit Donor Darah Palang Merah Indonesia DKI Jakarta Province in 2023 Rusdi1, Annisa Alfazrin1, Kadek Vicky Cintya Dewi1, Shofa Fauziah,1 Daniar Setyo Rini,1 Ni Ken Ritchie,2 Sumiyati2 Nurhayati2 1Departement of Biology Education, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Jakarta. 2 PMI Blood Donation Unit DKI Jakarta Province. Abstract The Blood Donor Unit (UDD) is a unit that facilitates the community, especially in the field of blood services, under the auspices of the Indonesian Red Cross (PMI). Some of the activities at UDD PMI include providing blood and distributing blood. Before blood is given to the recipient, it must first pass testing, namely the Infection Transmitted Through Blood Transfusion (IMLTD) screening test to prevent the risk of disease transmission. The aim of this research is to determine the results of examinations for Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV), and Syphilis at UDD PMI DKI Jakarta Province in 2023. This research uses secondary data from January to December 2023 obtained from archives of screening tests and screening results for infectious infections through blood transfusion (IMLTD) on donor blood at the PMI DKI Jakarta Blood Donor Unit (UDD) in 2023. This research was conducted in February-April 2024. Detection of Infectious Infections Through Transfusion Blood (IMLTD) was performed using the chemiluminescence immunoassay (ChLIA) technique. The results show that of the 368,615 samples submitted, 3,429 samples fell into the reactive category. The number of reactive donors in 2023 for Hepatitis B testing will be 1078 (0.29%), Hepatitis C will be 796 (0.22%), HIV will be 360 (0.10%), and Syphilis will be 1195 (0.32%). The most reactive donors in 2023 for Hepatitis B will be in July, for Hepatitis C will be in December, for HIV will be in March, and for Syphilis will be in April. Keywords: hepatitis- HIV- IMLTD- screening- syphilis. Share Link | Plain Format | Corresponding Author (Rusdi Rusdi)

27	Biology	ABS-84
Effect of Stocking Density Difference with the Same Amount of Feed on the Growth and Survival of Koi Fish (Cyprinus rubrofuscus) at the Balai Riset Budidaya Ikan Hias (BRBIH), Depok, West Java, Indonesia Rusdi,1 Muhamad Gilang Permana1, Rafika Dinillah1, Siti Nurlaela1, Fitria Pusparini1, Nina Meilisza2, and Joni Hariyadi2 1Biology Education Major, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta 2Balai Riset Budidaya Ikan Hias (BRBIH), Depok, Indonesia *Corresponding author rusdi[at]unj.ac.id Abstract Koi fish (Cyprinus rubrofuscus) have high aesthetic appeal and promising economic value, making them highly sought after by fish farmers. However, the primary challenge in koi fish farming is determining the most efficient and effective conditions, particularly regarding stocking density and optimal feed amounts. This study aims to evaluate the effect of different stocking densities on koi fish larval survival. An experimental method with a simple random sampling design was used, where research subjects were randomly selected and divided into three treatment groups. Each treatment was repeated three times to ensure the accuracy and consistency of results. Three different stocking densities were tested, namely 250, 500, and 750 fish per aquarium with a water volume of 48 liters. The main parameters observed included length, weight, specific growth rate, and larval survival rate. The data obtained were statistically analyzed to determine the significance of differences between treatments. Data were analyzed using ANOVA to test for variations between treatments, followed by Tukey^s test for post-hoc comparisons. The results showed that different stocking densities did not significantly affect the length and weight of the fish, but significantly affected larval survival. Treatment with a stocking density of 250 fish per aquarium resulted in the highest survival rate of 30.13%, indicating that a lower stocking density provided better conditions for koi larvae to survive. These findings provide important guidance for cultivators in optimizing koi fish cultivation efficiently and sustainably. Keywords: Cyprinus rubrofuscus, cultivation, stocking density, survival Share Link | Plain Format | Corresponding Author (Rusdi Rusdi)

28	Biology	ABS-103
Identification and Prevalence of Parasites in Dogs and Cats at Puskeswan Ragunan DKI Jakarta Fitria Pusparini, Hanifa Raiha Zahratina, Revita Alief Pramesti, Rimba Liewa Dinta Diputri, Refirman Dj., Ramzi Universitas Negeri Jakarta Abstract The aim of the research was to identify the type of parasite and the prevalence of parasitic infections in dogs and cats examined at the Diagnostic Laboratory at the DKI Jakarta Health Center. A total of 292 dog and cat samples in the form of earwax samples, skin scrapings, feces and blood tests were identified using native methods or direct examination under a microscope. The research results revealed that the type of parasite that infects dogs and cats is the ectoparasite Lynxacarus sp. as much as 1%, Otodectes sp. 10%, Sarcoptes scabiei 6%, and the endoparasite type Dipylidium sp. as much as 3%, Eimeria sp. 2%, Strongylus sp. 2%, Toxocara sp. 7%, as well as the blood test parasite Anaplasma sp. as much as 3%. In addition, it was found that the prevalence of parasitic infections in Puskeswan DKI Jakarta was 34%. The conclusion of this study is that the dogs and cats examined at the DKI Jakarta Health Center were infected with parasites with the usual infection prevalence rate or in the general category. Keywords: Parasites, Identification, Prevalence, Parasitic Infection Share Link | Plain Format | Corresponding Author (Fitria Pusparini)

29	Biology	ABS-107
MOLECULAR DOCKING ANALYSIS OF ACTIVE GENISTEIN COMPOUND FROM LILY FLOWER (Lilium longiflorum) PLANT TO ALPHA ESTROGEN RECEPTOR IN BREAST CANCER Fajarani Fitriasih (a*), Hanum Isfaeni (b) a) Magister Program of Biology Education, Department of Biology Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta. Jl. R. Mangun Muka Raya No.11, RT.11/RW.14, Rawamangun, Kec. Pulo Gadung, Kota Jakarta Timur, Daerah Khusus Ibukota Jakarta 13220 b)Doctor Program of Biology Education, Department of Postgraduate Biology Education, Faculty of Mathematics and Natural Sciences, State University of Malang, Malang, Indonesia Abstract Breast cancer is the highest mortality disease on women in the world and about 60-80% of the cases are ER alpha breast cancer. The discovery of more selective to ER alpha, safe, and potential new anticancer agent is expected to help the treatment of ER alpha breast cancer. In silico analysis had been carried out by computational chemistry methods, including determination of physicochemical parameters such as lipophilicity/Clog P, molar refractivity/CMR, bond energy/HOMO-LUMO and E-Gap, partial charge reactivity- determination of structural similarity by overlaying, and the interaction analysis of genistein and its analogues against HER alpha- by docking method. The goal of drug design is to find a chemical compound that can interact well with receptors. One method that can be used to design new drugs namely molecular docking. The purpose of this study is to carry out molecular docking simulations and tests Genistein toxicity as an Esterogen Receptor Alpha (ESR 1) inhibitor in breast cancer. Based on the results of docking the ESR1 target protein with the Genistein compound, it was obtained the RMSD value is 0 and the binding affinity value is -7.7. RMSD value 0 indicates that the conformation of the native ligand as a result of docking is close to the actual conformation. Keywords: Ganestein, Esterogen Receptor Alpha, Breast Cancer, Molecular Docking Share Link | Plain Format | Corresponding Author (Fajarani Fitriasih)

30	Biology	ABS-109
Numerical Literacy Profile of Biology Students in Plant Physiology Practicum and Level of Conceptual Change Sariwulan Diana Program Studi Pendidikan Biologi, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudi No. 229, Bandung 40154, Indonesia Abstract Plant physiology is material that is considered difficult and studying it requires adequate numeracy literacy, especially in practicums. Thus, it is necessary to reveal the student^s numeracy literacy profile and the level of conceptual change, before and after the practicum. This study used a pre-experimental design pre-test and post-tests group. The pre-test regarding numeracy literacy which refers to the Minimum Competency Assessment is given to Biology Education Department students who are contracting the Plant Physiology course in the odd semester 2022/2023, conducted before practicum about accumulation of mineral nutrients in plant cells, nutrient culture, water potential and osmotic potential. After each practicum, students are assigned to answer response questions, and ends with a post test. The results showed that there was an increase in student numerical literacy from the very low category (42.7) into the moderate category (62.1) with level of conceptual change in the construction and N-gain in low categories. Although it has the potential to improve students^ numeracy literacy, the Plant Physiology practicum needs to be improved, for example involving practical students in preparing substances and strengthening the lecturers in responses. Keywords: Numerical literacy, plant physiology practicum, conceptual change Share Link | Plain Format | Corresponding Author (Sariwulan Diana)

Page 1 (data 1 to 30 of 171) | Displayed ini 30 data/page
1 2 3 4 5 6 NEXT >>

Powered By Konfrenzi Ultimate 1.832M-Build8 © 2007-2024 All Rights Reserved