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61	Chemistry	ABS-53
inlJ Gene as a Potential Target Region for Detection of Listeria monocytogenes using real-time Polymerase Chain Reaction Jefferson Lynford Declan1,2, Muktiningsih Nurjayadi1,2, Gladys Indira Putri1,2, Dandy Akbar Juliansyah1,2, Ismaya Kridawati1,2, Irvan Maulana1,2, Maharanianska Azzahra1,2, Siti Fatimah2, Irma Ratna Kartika1,2, Fera Kurniadewi1,2, Vira Saamia3, I Made Wiranatha3, Shyi-Tien Chen4, Bassam Abomoelak5, Hesham A. El Enshasy6,7,8 1Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 2Research Center for Detection of Pathogenic Bacteria, Lembaga Penelitian dan Pengabdian Kepada Masyarakat, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 3Center Forensic Laboratory of the Criminal Investigation, Police of the Republic of Indonesia, Cipambuan Babakan Madang, Bogor, 1681, Indonesia. 4Department of Safety, Health and Environmental Engineering, National Kaohsiung University of Science andTechnology, No. 1 University Road, Yanchao District, Kaohsiung City 82445, Taiwan 5Arnold Palmer Hospital Pediatric Specialty Diagnostic Laboratory, Orlando, FL 32806, USA. 6Innovation Center in Agritechnology for Advanced Bioprocessing (ICA), Universiti Teknologi Malaysia (UTM), Pagoh, Johor, Malaysia. 7School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. 8City of Scientific Research and Technology Applications, New Burg Al Arab, Alexandria, Egypt. Abstract \(Listeria\) \(monocytogenes\) is a gram positive, rod-shape, and facultative anaerobic bacteria that cause food poisoning. These bacteria can cause listeriosis, with mild symptoms and even death with a mortality rate of up to 30%. This study aims to determine the potential of the \(inlJ\) gene fragment as a rapid detection with real-time Polymerase Chain Reaction for \(L.\) \(monocytogenes\). \(inlJ\) is a virulence factor of \(Listeria\) \(monocytogenes\) that contribute to attachment these bacteria to the host cells. This study used the DNA of \(L.\) \(monocytogenes\) with purity around 1.802 for A260/280 ratio and for amplification using concentration at 50ng/\(\mu\)L. The annealing temperature obtained from this research is 60 degrees Celsius based on the band in electrophoresis. The primer successfully amplifies the fragment of \(inlJ\) gene both PCR and rt-PCR with the amplicon size 200 bp and Ct at 15.95\(\pm\)0.3. This primer also can differentiate target and non-target bacteria based on the Ct and Tm values on rt-PCR. In addition, this primer success to detect DNA of \(L.\) \(monocytogenes\) as low as 71,3pg/\(\mu\)L. Based on this study, this primer has the potential to detect \(Listeria\) \(monocytogenes\). In the next step, it is necessary to examine the detection ability on artificial samples. Keywords: inlJ gene, Listeria monocytognes, Foodborne pathogen, Detection method, real-time PCR Share Link | Plain Format | Corresponding Author (Jefferson Lynford Declan)

62	Chemistry	ABS-54
Development of Electronic Module for Colloid Practicum in High School Based on STEM-Cased Based Learning Siti Fatimah1,3, Muktiningsih Nurjayadi1,2,3, Fera Kurniadewi1,2, Ririn Gustini1, Uswatul Nisa1, Athiyah Layla1, Mellyna Fitriani1, Annisa Maharani1, Sarah Adilisa Kartini1, Nasywa Fhelia Salta1, Nabilla Anisa Putrie1, Nida Nur Afifah1, Rizkahana Syehfia1, Jefferson Lynford Declan2,3 1Department of Chemistry Education, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 2Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 3Research Center for Detection of Pathogenic Bacteria, Lembaga Penelitian dan Pengabdian Kepada Masyarakat, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. Abstract Practicum is an important part of the chemistry learning process, providing students with direct experience that helps them think and work scientifically. This research aims to produce a colloid practicum e-module based on STEM-Case Based Learning. The research method used is research and development, employing the Borg&Gall model. The developed practicum e-module was created with Flip PDF Pro and includes an introduction, case studies, material (such as understanding colloid systems, the Tyndall effect, properties of colloids, and making simple colloids), images, videos, and a summative assessment at the end of each chapter. The STEM components of the colloids e-module include: (1) Science, which involves students^ understanding of simple chemicals that can be used in practical work- (2) Technology, which involves producing digital information in the form of practical videos- (3) Engineering, which involves designing and conducting experiments with simple materials- and (4) Mathematics, which involves analyzing and solving problems mathematically. The e-module has been validated by experts, receiving assessments ranging from 70-100% by media and material experts. Small-scale trials received scores ranging from 63-100%, while large-scale trials scored between 75-100%. Based on these results, it can be concluded that the e-module is categorized as good for use in chemistry learning. Keywords: Case-Based Learning, Colloids, Practicum E-Module, STEM Approach Share Link | Plain Format | Corresponding Author (Siti Fatimah)

63	Chemistry	ABS-57
Development of Interactive E-Module Based on Process Oriented Guided Inquiry Learning (POGIL) to Improve Students^ Critical-Thinking Ability on Stoichiometry Material Siti Zahroni1, Erdawati1,2, Siti Fatimah1,3, Muktiningish Nurjayadi 1,2,3 1Departement of Chemistry Education, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 2Departement of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 3Research Center for Detection of Pathogenic Bacteria, Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. Abstract This study aims to produce an electronic module or interactive e-module based on Process Oriented Guided Inquiry Learning (POGIL) in chemistry learning stoichiometry material to improve students^ critical-thinking skills. This type of research is a mixed method research. Qualitative methods are carried out with the Borg and Gall model RnD approach, from the e-module product development stage to the feasibility test of teachers and students. The quantitative method was conducted at the implementation stage of e-modules in learning. This research was conducted at SMAN 71, SMAN Muhammadiyah 11 Jakarta, and SMAN 40 Jakarta from November 2021 to June 2024. Product implementation used a purposive sampling design in experimental and control classes to test the effectiveness of e-module products. The results showed that the interactive e-module on stoichiometry material was feasible as a learning media. The average results of the experimental class in the pre and post tests were increased from 44.2 to 80.7. Statistical tests conducted with the Mann-Whitney Test showed a U-value of 113, a W value of 578, and a Sig or P-Value of 0.000 <0.05. The test results illustrate that learning chemistry by utilizing POGIL-based interactive e-modules makes a significant difference in students^ critical-thinking skills on stoichiometry material. Keywords: Chemistry Electronic Module, Stoichiometry, POGIL, Critical Thinking Share Link | Plain Format | Corresponding Author (Siti Zahroni)

64	Chemistry	ABS-60
Anti Elastase and Anti Tyrosinase Activities from The Pericarps Extract from Garcinia tetandra Pierre a,b Neneng Siti Silfi Ambarwati, c,Berna Elya, d,Yesi Demiaty, e,Agnes Nabela, e,Yulia Triyani a Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Pulogadung, Jakarta Timur, DKI Jakarta, 13220, Indonesia b Research Center for Cosmetics, Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Pulogadung, Jakarta Timur, DKI Jakarta, 13220, Indonesia c Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424 West Java, Indonesia dDepartment of Phytochemistry, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia e Department of Pharmaceutical Biology, Faculty of Pharmacy and Science, Muhammadiyah University of Prof. Dr. HAMKA, Jakarta, 13460, Indonesia Abstract Skin aging can be inhibited by reducing the action of the proteinase elastase enzyme and hyperpigmentation can be treated by inhibiting tyrosinase activity. The current study aimed to assess anti elastase and anti tyrosinase from Garcinia tetandra Pierre and investigate its flavonoid constituents. The extraction used maceration, with the ethyl acetate extract yielding 6.12 percent and the n hexane extract is 8.64 percent. In a series of in vitro assays, anti elastase (porcine pancreatic elastase) and anti tyrosinase (mushroom lyophilized powder tyrosinase) activities of various extracts of pericarps were evaluated. The assays used by microplate spectrophotometric method at a wavelength of 405 nm (for anti elastase assay) and 490 nm (for anti tyrosinase assay). The flavonoid content of the constituents was carried out on the extracts by AlCl3 method and measured using at 425 nm UV visible spectrophotometer. According to the findings, ethyl acetate extracts displayed the highest elastase inhibition (79.91) at 100 ppm and total flavonoid content 0.07 percent quercetin equivalent. The n hexane extract elastase inhibitory activity has resulted (73.78) better than quercetin as a positive control (65.97). According to the findings, n hexane extracts displayed the highest tyrosinase inhibition (53.83) at 100 ppm and total flavonoid content (1.27 percent quercetin equivalent), even though the result is lower than the kojic acid as a positive control (65.07). The flavonoid and phenolic acids can help with anti elastase inhibition activity. Implicating the research are the extracts for healthy and beauty, like skin protection, anti aging and product development potential. Keywords: anti tyrosinase, anti elastase, Garcinia tetandra Pierre, pericarps Share Link | Plain Format | Corresponding Author (Neneng Siti Silfi Ambarwati)

65	Chemistry	ABS-61
Mundu Leaves (Garcinia dulcis (Roxb.)Kurz: Antioxidant and Inhibitory Activity of The Tyrosinase Enzyme 1 Neneng Siti Silfi Ambarwati, 2 Rini Prastiwi, 2 Banna Agistananda, 2 Dian Nivari, 2 Hanifah Wafa Azmi, 2 Ema Dewanti, 3 Hadi Sunaryo, 2 Yulia Triyani, 4 Muhamad Sharul Nizam Awang 1Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Pulogadung, Jakarta Timur, DKI Jakarta, 13220, INDONESIA- 2Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof.Dr. HAMKA, Jakarta 1340, INDONESIA 3Department of Pharmacology, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof.Dr. HAMKA, Jakarta 1340, INDONESIA 4Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur Abstract Introduction: Indigenous to Indonesia, Mundu (Garcinia dulcis (Roxb.) Kurz.) is a local plant known for its robust antioxidant properties and ability to inhibit the tyrosinase enzyme. Objective: This study assesses the total phenolic content, total flavonoids content, antioxidant activity, and tyrosinase inhibitory potential of Mundu leaf extracts and their fractions. Methods: Mundu leaves underwent maceration using 70 percent ethanol for extraction, followed by fractionation with n hexane, ethyl acetate, and methanol. The resulting ethanol extract and fractions were then analyzed for antioxidant activity using the FRAP and DPPH methods, tyrosinase enzyme inhibition, and total phenol and flavonoid levels. Results: Fraction 2 exhibited the highest total phenol content at 831.3469 mg GAE/g, and fraction two also showed the highest flavonoid content at 82.4147 mg QE/g. The most potent antioxidant activity was observed in fraction 2, recording 2192.3162 mol/g with the FRAP method and an IC50 value of 11.8205 with the DPPH method. Additionally, fraction 2 demonstrated significant tyrosinase enzyme inhibition, with an IC50 value of 64.6316, indicating its superior activity compared to other extracts and fractions. Conclusion: These findings suggest that Mundu leaves have potent antioxidant activity and effective tyrosinase enzyme inhibition. Keywords: Mundu, Garcinia dulcis, Antioxidants, Tyrosinase. Share Link | Plain Format | Corresponding Author (Neneng Siti Silfi Ambarwati)

66	Chemistry	ABS-63
The Effect of Small-Scale Practical Kit and Practical Instruction Flipbook on Students Learning Motivation in Acid-Base Material Ely Puspita Sari1, Muktiningsih Nurjayadi1,2,3, Fera Kurniadewi1,2, Siti Fatimah1,3 1Department of Chemistry Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Jakarta, Gedung KH. Hasjim Asjari. Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia 2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Jakarta, Gedung KH. Hasjim Asjari. Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia 3Research Center for Detection of Pathogenic Bacteria, Lembaga Penelitian dan Pengabdian Kepada Masyarakat, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia Abstract This study aims to determine the effect of a small-scale practicum kit and a flipbook of practicum instructions on students learning motivation in acid-base material. This type of research is a quasi-experiment with a pretest-posttest design. This research was conducted in January 2024 at SMAN 15 Tangerang Regency. Data analysis used an independent t-test with the SPSS 26.0 application. The results of the independent t-test were 0.016 so H1 was accepted. Based on the data analysis, there was a difference in learning motivation values in the experimental class and the control class. In the experimental class, learning used a small-scale practicum kit and a flipbook of practicum instructions, while in the control class, large-scale practicum tools and student worksheets were used. The average post-test score in the experimental class was 60.04 and in the control class, it was 52.08. This study can conclude that using a small-scale practicum kit and a flipbook of practicum instructions has a positive effect on students^ learning motivation in acid and base material. Keywords: Practical tools, Small Scale Chemistry, Flipbook, Learning motivation, Acid-base Share Link | Plain Format | Corresponding Author (Ely Puspita Sari)

67	Chemistry	ABS-64
Impact of Air Pollution in Urban Areas: Knowledge and Attitudes of Parents towards Environmental Health Mitigation of Children in the Jakarta City Dwi Atmanto- Elvyra Yulia, Eti Herawati Environmental Education Study Program, Postgraduate Program, Universitas Negeri Jakarta Abstract Air pollution in big cities like Jakarta has an impact on health and the economy, which is detrimental to the community, especially children. This air pollution is very worrying, while areas of potential air pollution are facilities that are often visited by children, such as roads around schools and playgrounds. This research aims to determine the relationship between the knowledge and attitudes of parents in mitigating children^s environmental health and the impact of air pollution. The research method is a quantitative correlational survey. The research location is in the city of Jakarta in people who live near roads or areas affected by air pollution. The number of respondents was 75 parents who had children aged 5-17 years. Data was collected using SPSS. The results of the research show that (1) there is a relationship between parental knowledge about air pollution and children^s environmental health mitigation (0.00 < 0.05), (2) there is a relationship between attitudes and children^s environmental health mitigation (0.00 < 0.05), (3) there is a relationship between desire acting on air pollution on mitigating children^s environmental health (0.002 < 0.05), and (4) there is a relationship between knowledge of the impact of air pollution, air pollution attitudes, and the desire to act on mitigating urban air pollution together on parental behavior in mitigating children^s environmental health (0.00 < 0.05), with an influence contribution of 54.8%. Almost all respondents (90%) agreed that improving air quality is the responsibility of every citizen. Resources must be allocated to educate citizens about air pollution issues with appropriate practices to help reduce the adverse impacts on their families, especially children^s environmental health. Keywords: Knowledge, air pollution, attitudes, behavior, parents, mitigation, health, environment, children Share Link | Plain Format | Corresponding Author (Dwi Atmanto)

68	Chemistry	ABS-65
Vulnerability and Factors Affecting Public Health Resilience Related to Clean Water Sanitation in Coastal Areas, Muara Gembong District, West Java Dwi Atmanto- Elvyra Yulia- Eti Herawati Cosmetology Study Program, Engineering Faculty, Universitas Negeri Jakarta Abstract Muara Gembong is located on the north coast of Java Island, close to the city of Jakarta, and has a relatively high threat of environmental health degradation. In the Muara Gembong area, land control and land conversion are the main problems for water quality in residential areas, apart from that, the water quality of the Citarum River which passes through the area in several locations is polluted so that it cannot be used as clean water. The study^s goal is to investigate the vulnerability and factors impacting the health resilience of populations who utilize groundwater daily. This research uses qualitative and quantitative correlational. Data collection techniques using questionnaires on 40 respondents who live in the Pantai Mekar Village area, Muara Gembong District, West Java. There are 3 hypotheses proposed and processed using SPSS. This study found that the environmental health of the coastal area of Muara Gembong District, West Java, including sanitary facilities and clean water, is still very concerning. This lack of optimal water sanitation is indicated by the vulnerability to infectious diseases and infectious diseases in the community. Other research results are (1) there is a relationship between knowledge of groundwater quality and community health resilience (0.000 < 0.05), (2) there is a relationship between water environmental sanitation behavior in coastal areas and the health resilience of communities using coastal groundwater (0.002 < 0.05) and (3) ) there is a relationship between groundwater quality knowledge and environmental sanitation behavior in coastal areas with the health resilience of groundwater user communities (0.001<0.05). The contribution of groundwater quality knowledge and coastal water environmental sanitation behavior to the health resilience of coastal groundwater user communities is 65.9%. Keywords: Vulnerability, Knowledge, clean water quality, Water environmental sanitation, behavior, Community health resilience, Coastal areas. Share Link | Plain Format | Corresponding Author (Dwi Atmanto)

69	Chemistry	ABS-70
Development of an Eco-STEAM-based Electronic Practicum Module on Green Chemistry in Sustainable Development Annisa Maharani1, Muktiningsih Nurjayadi1,2,3, Yusmaniar1,2, Siti Fatimah1,3, Sarah Adilisa Kartini1, Athiyah Layla1, Mellyna Fitriani1, Nasywa Fhelia Salta1, Nabilla Anisa Putrie1, Jefferson Lynford Declan2,3 1Department of Chemistry Education, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 2Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 3Research Center for Detection of Pathogenic Bacteria, Lembaga Penelitian dan Pengabdian Kepada Masyarakat, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. Abstract The Green Chemistry subject expects Phase E students to be competent to apply chemical concepts in environmental management. This study aims to create an Eco-STEAM-Based Electronic Practicum Module on Green Chemistry in Sustainable Development. This research uses the Borg & Gall development model with a quantitative descriptive analysis method. The module is developed with Flip PDF Pro which consists of materials, practicum procedures, virtual simulations, and comprehension tests. The Eco-STEAM aspects in the module include (1) Ecology, which is the process of analyzing environmental problems, (2) Science, which is a discussion of Green Chemistry principles, (3) Technology, which is a learning support tool, (4) Engineering, which is an implementation of practicum procedures, (5) Art, as students^ creativity, (6) Mathematics as the calculation. Content validation by material experts gave values between 80-96% while by media experts between 87-95%. The results of the assessment of teachers showed scores between 71-100%. The small-scale student assessments showed values between 71-100%, and on a large scale between 75-100%. Based on the assessment results, the module is feasible to use as a learning resource with accurate and rule-appropriate material so that learning objectives can be achieved properly. Keywords: Eco-STEAM Approach, Green Chemistry in Sustainable Development 2030, Practicum Electronic Module Share Link | Plain Format | Corresponding Author (Siti Fatimah)

70	Chemistry	ABS-71
Development of Guided Inquiry-Based Electronic Practicum Module Integrated with STEAM on Thermochemistry for Grade XI High School Athiyah Layla1, Muktiningsih Nurjayadi1,2,3, Darsef Darwis1, Siti Fatimah1,3, Mellyna Fitriani1, Annisa Maharani1, Sarah Adilisa Kartini1, Nasywa Fhelia Salta1, Nabilla Anisa Putrie1, Jefferson Lynford Declan2,3 1Department of Chemistry Education, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 2Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 3Research Center for Detection of Pathogenic Bacteria, Lembaga Penelitian dan Pengabdian Kepada Masyarakat, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. Abstract Chemistry learning is closely related to practicum activities that provide hands-on experience to find concepts and facts so students can develop scientific thinking skills and construct knowledge in improving understanding of the material. This research aims to produce an electronic practicum module based on STEAM integrated Guided Inquiry on thermochemistry material^s class XI of High School. The STEAM includes (1) Science- Students understand of simple chemicals that can be used in practicum, (2) Technology- It produces digital information in form of practicum videos by students, (3) Engineering- designing and implementing practicum activities, (4) Arts- students^ creativity in practicum activities, (5) Mathematics- analyzing and solving problems mathematically. The electronic module contains thermochemistry practicum materials by images, videos, and summative assessments with the Flip PDF Professional program. The research and development method of the Borg & Gall model with validation by experts was used in this study. The validation results showed a score of 80-100% from material and language experts and a score of 80-90% from media experts. Small-scale trials on students obtained scores of 75-100% and 67-100% for large-scale. The results of the developed electronic module show decent value category to be used in chemistry learning. Keywords: Electronic Practicum Module, Guided Inquiry, STEAM Approach, Thermochemistry, Research and Development Share Link | Plain Format | Corresponding Author (Siti Fatimah)

71	Chemistry	ABS-72
Development of Acid-Base Electronic Practicum Module Based on STEM Integrated REACT (Relating, Experiencing, Applying, Cooperating, and Transferring) Strategy Mellyna Fitriani1, Muktiningsih Nurjayadi1,2,3, Yusmaniar1,2, Siti Fatimah1,3, Athiyah Layla1, Annisa Maharani1, Sarah Adilisa Kartini1, Nasywa Fhelia Salta1, Nabilla Anisa Putrie1, Jefferson Lynford Declan2,3 1Department of Chemistry Education, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 2Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 3Research Center for Detection of Pathogenic Bacteria, Lembaga Penelitian dan Pengabdian Kepada Masyarakat, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. Abstract Practicum is often applied in acid-base topics and makes learning more meaningful because students can directly observe the chemical processes that occur during the practicum. This research aims to produce an acid-base practicum e-module based on STEM-REACT as a solution to the problems experienced by students during an acid-base practicum due to the lack of learning media to complement the practicum. The development of the e-module used the Borg & Gall research and development model. The learning stages in the e-module are arranged based on the REACT learning strategy, and the STEM aspects in the e-module include (1) Science, applying acid-base concepts in the practicum, (2) Technology, using soil meter and creating practicum videos, (3) Engineering, designing and conducting practicum according to systematic work steps, (4) Mathematics, analyzing and solving problems mathematically. The validation test percentages by content and language experts ranged from 80-100% and media experts ranged from 81-92%, with reliability values of 0.9268 for content and language experts, and 0.9538 for media experts. Small-scale e-module trials obtained a value of 63-100%, while large-scale trial results ranged from 67-100%, and teacher trial results ranged from 75-100%. Based on the assessments^ results, the e-module developed is suitable to use in chemistry learning. Keywords: Acid-Base, Electronic Practicum Module, REACT Learning Strategy, STEM Approach Share Link | Plain Format | Corresponding Author (Siti Fatimah)

72	Chemistry	ABS-73
Development of E-Module Based on Guided Inquiry Integrated Ethnoscience on Buffer Solution Material Sarah Adilisa Kartini1, Muktiningsih Nurjayadi1,2,3, Edith Allanas1, Siti Fatimah1,3, Annisa Maharani1, Athiyah Layla1, Mellyna Fitriani1, Nasywa Fhelia Salta1, Nabilla Anisa Putrie1, Jefferson Lynford Declan2,3 1Department of Chemistry Education, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 2Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 3Research Center for Detection of Pathogenic Bacteria, Lembaga Penelitian dan Pengabdian Kepada Masyarakat, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. Abstract Indonesia has a variety of cultures, ethnicities, religions, and traditions. There is a need for educational institutions to optimize the learning process with local wisdom values, which are starting to be neglected in learning, including chemistry learning. This research aims to develop an E-Module Based on Guided Inquiry Integrated with Ethnoscience on Buffer Solution Material as a solution in this problem. The research method used is descriptive quantitative with the ADDIE research design and development model. The results of development research on e-module feasibility testing for content and language components by experts have an assessment percentage between 83.3-94.4% and r = 0.98 in the excellent category, and the presentation and graphics components have an assessment percentage between 90.0-95.3% and r = 0.96 in the very good category. Meanwhile, participants^ assessments of the e-module had a rating percentage of between 88.5-99.0% in the good to outstanding category. It can be concluded that the e-module developed is suitable for use by participants, namely students and teachers, in learning buffer solution material. Keywords: Buffer Solution, Electronic Module, Ethnoscience, Guided Inquiry Learning Model Share Link | Plain Format | Corresponding Author (Siti Fatimah)

73	Chemistry	ABS-75
Clidemia hirta Fruits Extract as Reaction Partner in Synthesis of Gold Particles Octakireina Liesaini Daefisal(a), Demi Dama Yanti(a), I Putu Mahendra(a), Muhamad Alvin Reagen(b), Sal Prima Yudha (b,c) a) Department of Chemistry, Institut Teknologi Sumatera (ITERA), Way Huwi, Kec. Jati Agung, Kabupaten Lampung Selatan- Province of Lampung, Indonesia. b) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Bengkulu Jalan W.R, Supratman, Kandang Limun, Kota Bengkulu 38122, Indonesia c) Research Center of Sumatra Natural Products and Functional Materials (RC-SuNaPFuMa), Universitas Bengkulu, Kandang Limun, Kota Bengkulu, 38122, Indonesia Abstract The extract of Clidemia hirta fruit has been selected as a reaction partner with chloroauric compounds in reactions that produce gold nanoparticles. Extract Clidemia hirta fruit was obtained in a simple way by heating the fruit in demineralized water at 70 C. The extract obtained was mixed with a solution containing gold ions at room temperature. The reaction proceeded quickly, as indicated by the extract^s rapid change in color when added to the gold ion solution drop by drop. According to the Transmission Electron Microscope (TEM) analysis, the particle size was between nanosize and microsize. The analysis results using the particle size analyzer (PSA) show that the current condition gives a particle size average of 121 nm. Keywords: Gold particles, Clidemia hirta, reaction partner, room temperature Share Link | Plain Format | Corresponding Author (OCTAKIREINA LIESAINI DAEFISAL)

74	Chemistry	ABS-77
Synthesis and Characterization of Gold Nanoparticles Using Brucea Javanica Fruit Peel Extract Muhamad Alvin Reagen (1), Sal Prima Yudha S (1*), Octakireina Liesaini Daefisal (2), Morina Adfa (1), Aneela Anwar (3) (1)Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Bengkulu, Jalan WR. Supratman, Kandang Limun, Kota Bengkulu 38371 *sp.yudha.s.2022[at]gmail.com (2)Department of Chemistry, Faculty of Science, Institut Teknologi Sumatera, Jalan Terusan Ryacudu, Jatiagung, Lampung Selatan 35365 (3)Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan Abstract Synthesis of nanoparticles using plant extracts is easy to do. Gold nanoparticles are synthesized using Brucea javanica fruit peel extract. each young fruit peel (Au-1) and young fruit peel (Au-2) were weighed 1 gram and extracted using 100 mL of DM aquarium solvent for 20 minutes at 60oC. synthesis of gold nanoparticles using the precursor HAuCl4 0.01 M. synthesis was carried out with a ratio of 4 (extract) : 1 (HAuCl4 0.01 M). Analysis using a UV-Vis spectrophotometer produced a wavelength of Au-1 at 553 nm and Au-2 at 564 nm. TEM analysis provides information that the gold nanoparticles produced are speric and nano in size. This is supported by the distribution of particles using PSA that gold particles are nano-sized through this synthesis with an even distribution. Keywords: Brucea javanica, HAuCl4, Gold Nanoparticles Share Link | Plain Format | Corresponding Author (Muhamad Alvin Reagen)

75	Chemistry	ABS-88
The Potential of htrA Gene to Identify Enterococcus faecalis using real-time Polymerase Chain Reaction Irma Ratna Kartika1,2, Grace1,2, Ananda Indah Putri Sihombing1,2, Agus Setiawan1,2, Anisa Fitriyanti1,2, Helzi Angelina1,2, Gusti Angieta1,2, Puan Aqila Azizah1,2, Royna Rahma Musie1,2, Dandy Akbar Juliansyah1,2, Jefferson Lynford Declan1,2, Gladys Indira Putri1,2, Siti Fatimah2, Ayu Berkahingrum1,2, Fera Kurniadewi1,2, Bassam Abomoelak3, Hesham A. El Enshasy4,5,6, Muktiningsih Nurjayadi1,2 1Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 2Research Center for Detection of Pathogenic Bacteria, Lembaga Penelitian dan Pengabdian Kepada Masyarakat, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia. 3Arnold Palmer Hospital Pediatric Specialty Diagnostic Laboratory, Orlando, FL 32806, USA. 4Innovation Center in Agritechnology for Advanced Bioprocessing (ICA), Universiti Teknologi Malaysia (UTM), Pagoh, Johor, Malaysia. 5School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. 6City of Scientific Research and Technology Applications, New Burg Al Arab, Alexandria, Egypt. Abstract \(Enterococcus\) \(faecalis\) is known as the opportunistic pathogens that can cause a variety of diseases. These bacteria are capable of producing enterotoxins that lead to gastrointestinal symptoms. This study aims to develop a real-time Polymerase Chain Reaction (PCR) method that is more efficient for identifying \(Enterococcus\) \(faecalis\) by assessing the results of the confirmation and specificity test of the htrA primer. The concentration of isolated DNA is 107 ng/\(\mu\)L, and the purities of A260/280 are 2.02. \(htrA\) primer successfully amplified \(Enterococcus\) \(faecalis\) DNA fragments at an annealing temperature of 60-62 degrees Celsius with an amplicon length of 162 base pairs. These pairs of primers amplified target sequences at a Ct value of 17.62\(\pm\)0.11 and a Tm value of 81.21 degrees Celsius \(\pm\)0.06. Specificity tests showed that the \(htrA\) primer could distinguish between target and several non-target bacteria. Based on these results, it can be concluded that the \(Enterococcus\) \(faecalis\) can be efficiently identified by these primers utilizing the real-time PCR. In order to create sensitive and specific detection methods, the next procedure will involve generating \(htrA\) primers to identify \(Enterococcus\) \(faecalis\) in sensitivity testing and artificially contaminated samples. Keywords: htrA gene, Enterococcus faecalis, pathogen, detection, diseases, real-time PCR Share Link | Plain Format | Corresponding Author (Irma Ratna Kartika)

76	Chemistry	ABS-90
Synthesis SnO2-SiO2 Using Palm Leaves As A Potential Source Of Silica Setyo Eko Nugroho (a), Sal Prima Yudha S (*a) Evi Maryanti (a), Muhamad Alvin Reagen (a) (a) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Bengkulu, Jalan WR. Supratman, Kandang Limun, Kota Bengkulu 38371 (*) sp.yudha.s.2022[at]gmail.com Abstract This research purpose is to use oil palm leaves as a source of silica in the synthesis of SnO2-SiO2 composites. Oil palm leaves were prepared by leaching method with 10% HCl to increase the silica content. SnO2-SiO2 was synthesised using the solid-state method with the help of a small amount of solvent. FTIR analysis showed Si-O-Si and O-Si-O peaks at wave numbers 1067.32 cm-1 and 796.38 cm-1 and Sn-O-Sn peak at wave number 541.87 cm-1. XRD analysis showed amorphous phase in SiO2 and crystalline phase in SnO2. The composite materials obtained have the potential to be utilised as adsorbents and catalysts in the wastewater purification process. Keywords: Oil Palm Leaves, SnO2-SiO2, Synthesis Share Link | Plain Format | Corresponding Author (Setyo Eko Nugroho)

77	Chemistry	ABS-101
Novel A New Benzenesulfonylurea-Substituted Pyridazinone Derivative with Antidiabetic Effect as the Peroxisome Proliferator-activated Receptor (PPAR-&#947-) Agonismple Abstract Yuni Fatisa, Elvi Yenti, Ihsan Ikhtiaruddin, Neni Frimayanti, Jasril, Arif Yasthophi mple Abstract Department of Chemistry Education, Faculty of Tarbiyah and Keguruan, Universitas Islam Negeri Sultan Syarif Kasim Riau, Pekanbaru, Indonesia Department of Chemistry, Faculty Mathematic and Natural Sciences, Universitas Riau , Pekanbaru, Indonesia Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Pekanbaru, Indonesia Abstract Peroxisome Proliferator-activated Receptor (PPAR-&#947-) protein is one of the target proteins for insulin sensitivity therapy in Type 2 DM patients. PPAR-&#947- has a key role as a nuclear receptor that regulates the expression of several genes related to metabolism. This research aims to synthesize a new benzenesulfonylurea-substituted pyridazinone derivative yaitu (E)-N^-(1-(4-(3-(4-methoxyphenyl)-6-oxopyridazin-1(6H)-yl)phenyl)ethylidene)-4-methylbenzenesulfonohydrazide (8) and predicted it activity as the PPAR-&#947- agonist using a molecular docking approach and ADMET profile. The new compound 8 was obtained through a Schiff base condensation reaction between compound 6 with p-tosyl hydrazine and a glacial acetic acid catalyst using monowave. The purity of this compound was determined by TLC test, melting point measurement and HPLC. The structure of synthesized compound was confirmed through UV spectroscopy, FTIR, 1H-NMR and HRMS analysis. Molecular docking studies were carried out on the crystal structure of the human PPAR-&#947- Ligand Binding Domain target protein in complex with the &#945--aryloxyphenyl acetic acid agonist (PDB ID 1ZEO). The results of the molecular docking study show that compound 8 has a lower binding free energy than rosiglitazone (positive control) with a free energy value (S score) = -13.513 kcal/mol and -8.3089 kcal/mol, respectively. Compound 8 can form hydrogen bonds with residues His323 and Ser289, &#960--&#960- interactions with Phe363 and &#960--H interactions with Cys285. The interaction of compound 8 is also similar to the interaction between the native ligand agonists &#945--aryloxyphenyl acetic acid and rosiglitazone with the target protein. Furthermore, compound 8 is predicted to have a moderate ADME profile. The results of this study support that compound 8 can be developed as a PPAR-&#947- agonist candidate for antidiabetic therapeutic agent. Keywords: benzenesulfonylurea-substituted pyridazinone derivative- PPAR-&#947-- monowave- molecular docking- ADMET Share Link | Plain Format | Corresponding Author (Arif Yasthophi)

78	Chemistry	ABS-108
Identifying Student Metacognitive Characteristics in Problem Solving on Hidydrocarbons Lesson Miterianifa (a*), Lidya Utari (b), Arif Yasthophi (c), Ira Mahartika (d)) a,b,c,d) Department of Chemistry Education Universitas Islam Negeri Sultan Syarif Kasim Jl. HR. Soebrantas, Pekanbaru, Riau 28293, Indonesia *miterianifa[at]uin-suska.ac.id Abstract Identifying metacognitive characteristics is important to see how far students are able to organize cognitive knowledge and regulation in learning. This research aimed at finding out student characteristics and metacognitive level at the eleventh grade of State Islamic Senior High School 4 Kampar. This research was carried out in the Academic Year of 2023/2024 at State Islamic Senior High School 4 Kampar with Hydrocarbons lesson. Quantitative descriptive method was used in this research. The samples were 13 students selected by using purposive sampling technique. The instruments used in this research were essay test questions and MAI questionnaires adapted to metacognitive indicators. The data analysis results of metacognitive characteristics for each indicator showed that the mean score for declarative indicator was 92.40% with very good category, procedural indicator was 60.26% with poor category, and conditional indicator was 59.62% with very poor category. In metacognitive level, the data analysis results of each indicator showed that, for cognitive regulation, the mean score obtained for the planning indicator was 85.54% with very good category, information management strategy was 77.56% with good category, monitoring of understanding was 76.93% with good category, debugging strategy was 90.38% with very good category, and evaluation was 81.41% with very good category- the cognitive knowledge of each indicator showed that the result for the declarative indicator was 79.62% with good category, the procedural indicator was 76.92% with good category, and the conditional indicators was 85% with very good category. It was hoped that the research findings could help teachers to better implement learning strategies that could facilitate students in improving metacognitive abilities. Keywords: Metacognitive Characteristics, Hydrocarbons Share Link | Plain Format | Corresponding Author (Miterianifa Miterianifa)

79	Chemistry	ABS-113
ANALYSIS OF SELF-CONFIDENCE OF CHEMISTRY EDUCATION STUDENTS IN UNDERSTANDING REDOX CONCEPTS: OXIDATION NUMBERS, CHARGE, AND ELECTRON TRANSFER Elma Suryani (a)*, Tritiyatma H (b), Hayyun Lisdiana (b), Edith Allanas (b). (a) Prodi Pendidikan Kimia, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Kota Jakarta Timur, Indonesia *elmasuryani[at]unj.ac.id (b) Prodi Pendidikan Kimia, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Kota Jakarta Timur, Indonesia Abstract This study aims to analyze the self-confidence of chemistry education students in understanding redox concepts, measured using the Redox Concept Inventory (ROXCI). The Redox Concept Inventory (ROXCI) instrument consists of 18 questions, each requiring students to indicate their confidence in their answers on a scale from 0 (just guessing) to 10 (completely sure). The confidence scale is included to help researchers understand the strength of students^ misconceptions and to demonstrate whether students seriously choose distractors representing their ideas. ROXCI was administered to first, second, third, and fourth-year chemistry education students. Group analysis was used to identify groups of students with similar response patterns based on total scores and average confidence on ROXCI. The research methodology employed was mixed methods with an explanatory design and post-positivism as the research paradigm. The study was conducted by collecting, analyzing, and integrating qualitative and quantitative data. The explanatory design (two-phase model) is a mixed methods design that involves collecting quantitative data first and then gathering qualitative data to explain the quantitative results. The research findings indicate the presence of three groups of students: a group with high scores and high confidence, a group with low scores and low confidence, and a group with low scores but high confidence. This research also demonstrates that there is a relationship between scores on understanding redox concepts and students^ self-confidence. Keywords: ROXCI, Redoks, Misconception, Self-Confidence Share Link | Plain Format | Corresponding Author (Elma Suryani)

80	Chemistry	ABS-117
Synthesis of silver nanoparticles using lemongrass leaf extract reductor (Cymbopogon citratus) and its application as a heavy metal sensor Yussi Pratiwi1, Yogi Febrian2, Chemistry Department, Mathematics and Natural Science Faculty, State University of Jakarta, Rawamangun, East Jakarta (13220), Indonesia 2Analytical Chemistry, State University of Jakarta, East Jakarta (13220), Indonesia Abstract A fast, effective and environmentally safe analysis method as a heavy metal sensor, namely silver nanoparticles synthesized with lemongrass leaf extract. The purpose of this study is to determine the optimal conditions for synthesis nanoparticles, characterize silver nanoparticles, and analyze the results of several method validation. The synthesis reaction under optimal conditions included a reaction time of 45 minutes, a concentration of AgNO3 used of 3 mM, and a concentration of 10% extract used to produce reddish-brown colloidal silver nanoparticles with a wavelength of 432 nm with a particle size distribution of 150.8 nm. GCMS in extract had the several ester compound. The results of the method validation have a linearity value of R2 = 0.9988 with the equation y = 0.04x + 0.0722. The selectivity results in mercury metal are effective at a concentration of 600 ppm. Based on the optimum conditions, linierity, selectivity, as well as sensitivity and LOD of silver nanoparticles synthesized with lemongrass leaf extract, it can potentially be an effective and simple mercury metal sensor. Keywords: Colorimetric Sensors, Lemongrass, Method Validation, Silver Nanoparticles Share Link | Plain Format | Corresponding Author (Yussi Pratiwi)

81	Chemistry	ABS-119
Synthesis Of Cellulose Nanofibers From Organic Peel Waste: An Acid Hydrolysis And Ultrasonication Approach Syukri Arief, Mailani Putri, Gusliani Eka Putri, Tio Putra Wendari, aDepartment of Chemistry, Universitas Andalas, Padang 25163, Indonesia bDepartment Biomedical Science, Universitas Syedza Saintika, Padang 25132, Indonesia Abstract Nanocellulose was successfully extracted from Nipah fruit peel (Nypa fruticans) fibers to study the characteristics of nanocellulose derived from natural materials. The extraction process involved several chemical pre-treatment steps, such as delignification and bleaching, to eliminate lignin, hemicellulose, and other extractive substances. Cellulose was then modified into nanoscale using both chemical methods like acid hydrolysis and mechanical methods such as ultrasonication. Fourier-transform infrared (FTIR) spectroscopy confirmed the successful removal of hemicellulose and lignin from the cellulose structure. X-ray diffraction (XRD) analysis showed that the crystal size and degree of crystallinity reached their peak values after acid hydrolysis, with a crystal size of 24.96 nm and a degree of crystallinity of 92%. However, after 120 minutes of ultrasonication, a reduction in crystal size to 13.86 nm and crystallinity to 85% was observed. Transmission electron microscopy (TEM) revealed that the produced nanocellulose displayed a nanofiber morphology, with diameters ranging from 15 to 20 nm. These results indicate that Nipah fruit peel fibers have significant potential as a commercially viable source of nanocellulose. Keywords: Nypa fruticans, cellulose, nanocellulose, acid hydrolysis, sonication Share Link | Plain Format | Corresponding Author (Syukri Arief)

82	Chemistry	ABS-120
Performance Improvement of Catalyst HZSM-5 Hierarchically through Nickel Impregnation for Cellulose Hydrolysis Reaction Mita Rilyanti (a*), Fransiska Valen Lintang Asmara (a), Annisa Distiani (a), Aprilia Sashya Kirana (a), Camelia (a), Mulyono (a), Suharso (a) (a) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Lampung University, Bandar Lampung-35141 (Indonesia) *mita.rilyanti[at]fmipa.unila.ac.id Abstract In this research, the synthesis of HZSM 5 and HZSM5 hierarchically based on silica bagasse ash (SCBA) was carried out using starch as Bio Mesoporogen. Efforts to improve catalyst performance were carried out by modifying the acid site through impregnation of nickel metal on the catalyst framework and its performance was studied in the hydrolysis reaction of banana peel cellulose. The characteristics of the extracted silica showed an amorphous phase with SiO2 and Al2O3 content percentage of 77.176 persen and 10.536 respectively and confirmed the presence of silanol functional groups and siloxane groups. SCBA silica was used to synthesize hierarchical pore ZSM 5 using a seeding technique via the hydrothermal method at a temperature of 180C for 144 hours. The hierarchical HZSM 5 and HZSM 5 catalysts showed a crystalline phase with crystallinity percentage of 86.13 and 70.41, respectively. The results of SEM analysis show differences in morphology where H-ZSM-5 is hexagonal (coffin type) while hierarchical HZSM 5 is in the form of small particles in the form of relatively uniform aggregates and a bulky shape with a surface area of 191.615 m2/g and a pore size distribution (PSD) 3.7 nm. Characterization of the hierarchical Ni/HZSM 5 and Ni/HZSM 5 catalysts shows that the Ni metal percentage contained in HZSM 5 is 0.490 and 0.298 respectively. The hierarchical Ni/HZSM 5 catalyst test obtained a cellulose conversion percentage of 76.68 with optimum reaction conditions, namely a temperature of 140 C for 3 hours with a catalyst/cellulose ratio of 3:5. This result is better than the percent conversion produced using the hierarchical HZSM 5 catalyst without Ni metal impregnation. Keywords: ZSM-5, impregnation, cellulose, hydrolysis, sugarcane bagasse Share Link | Plain Format | Corresponding Author (Mita Rilyanti)

83	Chemistry	ABS-123
Anticancer Potential of Ellagic acid rhamnoside from Shorea beccariana: In silico studies Abdullahi Musa Universitas Airlangga Abstract Natural products derived from plant have long been recognized as a valuable source of bioactive compounds that could be used in the development of therapeutic treatments, specifically for anticancer treatments. These compounds have played significant role in the advancements of drug discovery and development. Among the diverse array of plant species, the genus Shorea, which belongs to the family Dipterocarpaceae, has attracted attention due to its rich phytochemical profile and pharmacological properties. A bioassay-guided investigation of the wood of Shorea beccariana resulted in the isolation of 3-O-methylellagic acid 3^O-&#945--rhamnoside. The structure of this compound was determined using comprehensive structural elucidation techniques, including 1D and 2D NMR spectroscopy, UV spectroscopy, and FTIR analysis. Pharmacokinetic studies on the isolated compound demonstrated positive results, meeting several criteria for drug candidates, including bioavailability, ADMET and drug-likeness properties. Furthermore, in-silico molecular docking analysis of the compound using Dock6 revealed its ability to inhibit cyclin-dependent kinase 9 (CDK9) and 17&#946--hydroxysteroid dehydrogenase type 1 (HSD17&#946-1) enzymes at molecular level, with a good conformational interaction and binding free energy of -68.88 kcal/mol and -63.93 kcal/mol, respectively. The compound^s potent binding affinity with both target enzymes was found to be better than the reference inhibitors making it a highly promising candidate for an anticancer drug. However, further research on the molecular dynamic simulation and experimental validation (in vitro and in vivo studies) of the isolated compound is required in order to gain a deeper understanding of the underlying mechanisms behind this interaction. The isolated secondary metabolite compound is being reported for the first time from the plant species. Keywords: Ellagic acid, Anticancer, Shorea beccariana, CDK9, HSD17&#946-1. Share Link | Plain Format | Corresponding Author (Abdullahi Musa)

84	Chemistry	ABS-127
Transester Activity of Lipase from Pseudomonas sp. LPG171 Immobilized on Lampung Natural Zeolite Dian Herasari (1*), Bunga Mega Nurlinda (1), Mita Rilyanti (1), John Hendri (1) (1) Department of Chemistry, FMIPA, Universitas Lampung * dian.herasari[at]fmipa.unila.ac.id Abstract This study aims to determine the transester activity of the lipase enzyme Pseudomonas sp. LPG171 immobilized on Lampung natural zeolite (ZAL). The research stages began with the production of lipase from the bacteria Pseudomonas sp. LPG171, purification of lipase by ammonium sulfate fractionation and gel filtration column chromatography using Sephadex G5. The pure enzyme was then immobilized using ZAL from CV Minatama, Lampung. The immobilization process was evaluated by comparing the transester activity of free enzyme and immobilized enzyme at optimum enzyme conditions. Lipase hydrolysis activity was determined using the Kwon and Rhee method, while transesterification activity was determined using the Fu method. Concentration of protein was calculated based on the Lowry method. The results showed that the specific activity of lipase activity Pseudomonas sp. LPG171 increased at each purification stage, respectively by 21.25 U per mg for the enzyme crude extract, 94.95 U per mg for the ammonium sulfate fraction after dialysis, and 480.44 U per mg for the column chromatography fraction. The optimum conditions for immobilized lipase for its transester activity reached on pH 7, temperature 40degree Celcius, and incubation time of 10 minutes did not change compared to the free enzyme, except for the optimum temperature which shifted 5 degrees higher than the free enzyme. Repeated use of immobilized lipase up to 5 times reduced lipase activity by up to 45.31 percent. Keywords: Lipase, Pseudomonas sp. LPG171, immobilization, and Lampung natural zeolite Share Link | Plain Format | Corresponding Author (Dian Herasari)

85	Chemistry	ABS-139
ANALYSIS OF STUDENTS COGNITIVE STRUCTURE USING FLOW MAP METHOD IN RATE OF REACTION BY 8E LEARNING CYCLE MODEL Elma Suryani (a)*, Achmad Ridwan (b), Rizky Sulistyowati (b) (a) Prodi Pendidikan Kimia, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Kota Jakarta Timur, Indonesia *elmasuryani[at]unj.ac.id (b) Prodi Pendidikan Kimia, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Kota Jakarta Timur, Indonesia Abstract This research aims to determine students cognitive structure through flow map method on the Reaction of Rate materials using 8E Learning Cycle model. The subjects of this study were 33 students of grade XI. This research used qualitative methods. Data collection techniques were carried out through flow map, students worksheet, interview, reflective journal, observation, and comprehension test instrument. The data validity checks in this study were Prolonged Engagement, Member Checking, Persistent Observation, and Progressive Subjectivity. The data analysis technique used in this study is Miles and Huberman model, namely data reduction, data presentation, and drawing conclusions. Cognitive structure analysis was carried out by considering 6 cognitive structure variables based on Tsai, namely Extent, Richness, Integrations, Misconceptions, Information retrieval rate, and Flexibility. The results showed that, at the beginning of learning, the average number of students cognitive structure variables was low and number of misconceptions was high. Furthermore, the development of students cognitive structure show its development after participating in learning activities using the 8E Learning Cycle model. This shows that the 8E Learning Cycle model can help students develop their cognitive structure. Keywords: Cognitive Structure, Flow Map, 8E Learning Cycle, Rate of Reactions Share Link | Plain Format | Corresponding Author (Elma Suryani)

86	Chemistry	ABS-142
TRANSFORMATION OF BENTONITE INTO ZEOLITE-X AS CATALYST FOR PYROLYSIS OF CRUDE PALM OIL Wasinton Simanjuntak, Kamisah D. Pandiangan, Ilim, Adryan D. Dzulfiqar, Aditya A.Sahyani, Desrita Pratiwi, Khairi H. Febriana, Tyas Nurfitria, Bella Agustin, Melissaputri, Azizah Rosihana Tiara Putri Departement of Chemistry, Faculty of Mathematics and Natural Science, Lampung University, Lampung Abstract Abstract is submitted as file Keywords: bentonite, zeolite-X, pyrolysis, palm oil, bio crude oil Share Link | Plain Format | Corresponding Author (Wasinton Simanjuntak)

87	Chemistry	ABS-145
TRANSFORMATION OF BENTONITE INTO ZEOLITE-A AS CATALYST FOR PYROLYSIS OF CRUDE PALM OIL Kamisah Delilawati Pandiangan, Wasinton Simanjuntak, Diky Hidayat, Franky Gomgom N, Qori Hikmah Faranida, Maulana Bintang Rabbani, Muhammad Sabil, Diska Indah Alista, Nurul Fajriyati, Erwanda Lili Utari Department of Chemistry, Faculty of Mathematics and Natural Science, Lampung University, Lampung Abstract This research was carried out to study pyrolysis of crude palm oil using zeolite-A resulted from transformation of bentonite. Transformation of bentonite was attempted by adjusting the Si/Al ratio to 1.5 using food grade aluminium foil (FGAF) for addition of aluminium. A specified mass of FGAF was dissolved in sodium hydroxide solution to obtain sodium aluminate solution and then a specified mass of bentonite was added into the solution. The mixture was magnetically stirred to homogenized the sample and then transferred into Teflon lined autoclave. For crystallization process, the autoclave was placed in an oven set at 100 oC for 72 h. The produced solid was then subjected to calcination at different temperatures of 600, 700, and 800 oC for 8 hours, characterized using XRD and SEM, and then used as catalyst. The experimental results demonstrated that partial conversion of bentonite into zeolite-A was confirmed by XRD and SEM. Pyrolysis experiments demonstrated that the catalysts display promising potential as reflected by the presence of hydrocarbons as a main component with the highest relative percentage of 89.91% in the bio crude oil (BCO) produced with the use of catalyst calcined at 700 oC. Keywords: bentonite, zeolite-A, pyrolysis, palm oil, bio crude oil Share Link | Plain Format | Corresponding Author (Kamisah Delilawati Pandiangan)

88	Chemistry	ABS-146
The Effect of Differentiated Learning with Think-Tac-Toe Strategy on Students Learning Outcomes on the Topic of Buffer Solutions Elma Suryani(a*), Achmad Ridwan (b), Muthiah Nur Azzahra (b) (a) Pendidikan Kimia, Universitas Negeri Jakarta, Jalan Rawamangun Muka Raya 11, Ja-karta 13220, Indonesia elmasuryani[at]unj.ac.id (b) Pendidikan Kimia, Universitas Negeri Jakarta, Jalan Rawamangun Muka Raya 11, Ja-karta 13220, Indonesia Abstract The new curriculum in Indonesia known as Kurikulum Merdeka, emphasizes the importance of differentiated learning. This approach develops learning according to the needs of students who have a diversity of ability levels and different learning styles and interests. This study aims to determine the effect of a think-tac-toe strategy on students learning outcomes on buffer solution topics. The design of this study was a posttest-only control group design. The sample was randomized using the cluster random sampling technique to be selected as the experimental and control groups. The sample consisted of 66 students from XI classes at SMAN 55 Jakarta. Students were given a VARK learning style questionnaire to identify their learning styles. Student learning outcomes were obtained from a buffer solution post-test of 20 multiple-choice. Post-test data of experimental and control groups were analyzed with the Mann-Whitney U test, which showed significant differences in learning outcomes (Sig = 0.001- <0.05). Similar results were also shown in the comparison by students of visual groups (P = 0.004- <0.05) and reading groups (P = 0.019- <0.05- d = 1.388) using the independent t-test. The students of auditory groups also showed significant differences analyzed by the Mann-Whitney U test (Sig = 0.004- < 0.05). Nevertheless, no significant difference was observed in the students of kinesthetic groups analyzed using the independent t-test (P = 0.08- > 0.05). These results indicate that the think-tac-toe learning strategy effectively improves student learning outcomes. Keywords: Differentiated Instruction, think-tac-toe learning strategy, learning outcomes, buffer solution Share Link | Plain Format | Corresponding Author (Elma Suryani)

89	Chemistry	ABS-148
Development of e-book on medicinal plants of Rejang tribe supported by Articulate Storyline application as a learning resource for Natural Medicinal Chemistry Education Course Dewi Handayani (a)*, Salastri Rohiat (b), Sura Menda Ginting (c), Chairul Ichsan (d) a, b, c) Education Chemistry Study Program, University of Bengkulu, Indonesia *d.handayani[at]unib.ac.id d) UIN Raden Fatah Palembang, Indonesia Abstract This research aimed to identify medicinal plants utilized by the Rejang tribe in Rejang Lebong Regency, Bengkulu Province, to investigate the phytochemical profiles of these plants, and to assess the validity and student responses to an e-book developed based on the study^s findings. The research involved students enrolled in the Organic Chemistry of Natural Products course during the odd semester of the 2023/2024 academic year. Employing a Borg & Gall R&D model, the study was conducted in seven stages: (1) research and information gathering, (2) planning, (3) initial product development, (4) small-scale trials, (5) product revision, (6) limited trials, and (7) final product revision. Data collection techniques included interviews, field observations, validation sheets, and student response questionnaires. Twenty medicinal plants used by the Rejang community were selected for the study. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and terpenoids in varying concentrations within these plants. The e-book on medicinal plants of the Rejang people received an average validity score of 85.2% for content and 92.9% for media, placing it in the ^highly feasible^ category. Student responses to the e-book were positive, with scores of 86.1% for content, 88.4% for media, and 88.0% for usefulness, resulting in an average of 87.5%, categorized as ^very good.^ Keywords: E-book- Medicinal Plants- Articulate Storyline- Organic Chemistry of Natural Products- Rejang Tribe Share Link | Plain Format | Corresponding Author (Dewi Handayani)

90	Chemistry	ABS-152
Comparative Production of Protein Hydrolysate Using LSF and SSF Methods from Chicken Feather Waste by Isolate B-9-6: A Study to Determine the Most Effective Method Mulyono (a*), Alinil Masruroh (b), Gita Fitria (c), Dian Herasari (d) Department of Chemistry, FMIPA Universitas Lampung Jl. Soemantri Brodjonegoro No.1, Bandar Lampung 35145, Indonesia *mulyono[at]fmipa.unila.ac.id Abstract This study evaluated protein hydrolysate production from chicken feather waste using isolate B-9-6. Protein hydrolysates were produced using liquid (LSF) and solid (SSF) fermentation techniques. A UV-Vis spectrophotometer was used to conduct the protein hydrolysate assay stages, assess the degradation of the percentage of chicken feather waste, and ferment the waste for 12 days. SEM analysis, amino acid content, protein hydrolysate content, and proteolytic activity were also included in this study. The results of previous studies showed that 70% was the optimal degradation rate for the chicken feather waste using the LSF method. The LSF approach yielded the optimal amino acid content concentration at 0.93 U/mL, while the SSF method yielded the highest keratinase proteolytic activity assay findings at 0.93 U/mL. Keywords: Chicken feather- LSF- SSF, Keratinase Share Link | Plain Format | Corresponding Author (Mulyono SK)

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