Identification of Ascorbic-acid Compounds in Moringa Leaves (Moringa oleifera L.) as Anti- Inflammatories through Ligands in the Toll-Like Receptor Signaling Pathway for In Silico Prediction of Stunting Prevention
Henny Iriantini (a*), Hanum Isfaeni (b)

a) Master of Biology Education, Faculty of Mathematics and Natural Sciences, State University of Jakarta. Jl. Rawamangun Muka Raya No. 11, RT 11/RW. 14, East Jakarta 13220, DKI Jakarta, Indonesia.
*hennyiriantini639[at]gmail.com
b) State University of Jakarta. Jl. Rawamangun Muka Raya No. 11, RT 11/RW. 14, East Jakarta 13220, DKI Jakarta, Indonesia.

Abstract

Stunting is a condition of chronic malnutrition in toddlers. In the pathophysiology of stunting,
inflammation plays an important role by inducing growth hormone (GH) resistance, increasing
the body^s nutritional needs and anemia. Moringa leaves (Moringa oleifera) are useful in curing
24 chronic metabolic diseases including stunting. The aim of this study was to identify the bioactive
compound Moringa oleifera as an anti-inflammatory through its ligands in the Toll-like receptor
signaling pathway for the prediction of stunting prevention in silico. This research method is
descriptive exploratory using Dr.^s online database. Duke^s Phytochemical and Ethnobotanical
Databases, PubChem, PASS Online, SEA, SwissTargetPrediction, and STRING. The results
showed that the moringa plant has 6 bioactive compounds that have potential as anti
inflammatories, namely ascorbicacid, beta-carotene, caffeic-acid, kaempferol, quercetin,
tocopherol. Screening of target protein network construction obtained an anti-inflammatory
signaling pathway through the KEGG pathway Tolllike receptor signaling pathway and there are
9 target proteins that play a role in the signaling pathway, namely NF-kappa-B essential
modulator (IKBKG).

Keywords: Ascorbic-acid Moringa oleifera L., anti imflammatory ligand, stunting in silico

Topic: Biology