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1	Advanced health technology and medical treatment	ABS-4
Cut-Off Point Analysis for Type 2 Diabetes Mellitus Neuropathy Detection: Safety Test E-Skin Diabetic Simple Test Rahmat Bakhtiar(a*) Mayusef Sukmana(b) Yuliana Rahmah Retnaningrum(c) a) Faculty of Medicine, Departement of Public Health, Mulawarman University, Jalan Krayan Gunung Kelua, Indonesia, r.bakhtiar[at]fk.unmul.ac.id b) Faculty of Medicine Departement of Nursing, , Mulawarman University, Jalan Krayan Gunung Kelua, Indonesia, mayusef[at]fk.unmul.ac.id c) Faculty of Medicine, Departement of Internal of Medicine, Mulawarman University, alan Krayan Gunung Kelua, Indonesia,yulianakaltim[at]gmail.com Abstract Background: Peripheral neuropathy is the most common complication in DM patients, affecting 50% of type 2 DM patients. Early detection of sensory disturbances in diabetic neuropathy can be done through foot examination, not yet available in health services. Its interpretation can only diagnose loss of pain sensation while there is no temperature sensation. The E Skin Diabetic Simple Test is a tool that can diagnose the sensation of heat on the skin of the soles of the feet. Purpose: The purpose of this study was to analyze the tools safety and determine the tools temperature cut off point. Methods: The design of the study was a descriptive-analytic study. The inclusion criteria of healthy adults aged 18 to 25. The sampling technique was a random sampling of 103 respondents. Analysis using the frequency distribution test. This research was conducted at 2 (two) NCI Samarinda clinic locations and the D3 Nursing Study Program, Faculty of Medicine, Mulawarman University. Results: The Results study showed no skin damage by 100%. Complaints of burning sensation were not felt by 92.2% and complaints of burning sensation were felt by 7.8%. There was no feeling of electrocution as much as 87.4%. No sharp pain felt by 98.1%, and sharp pain felt yes by 1.9%. Other complaints are absent by 99% and other complaints are felt like tingling by 1%. Conclusion: The conclusion of the safety test results of the e skin diabetic simple test tool is proven safe, even though it has a risk of tissue damage, burning, electrocution, sharp pain and other complaints in the form of tingling. The temperature cut off point that the respondent felt for the first time was 43.58 C. Further research is needed with more samples in various subjects of patients with diabetes mellitus without complications and with complications. Keywords: Diabetic peripheral neuropathy- Neuropathy diagnostic tool Share Link | Plain Format | Corresponding Author (Mayusef Sukmana)

2	Advanced health technology and medical treatment	ABS-5
Development of A Temperature-based E-skin Test for Peripheral Diabetic Neuropathy Mayusef Sukmana(a) Rahmat Bakhtiar(b) Muhammad Aminuddin (c) Sholichin (d) Dwi Nopriyanto (d) Ediyar Miharja (e) Yuliana Rahmah Retnaningrum(f) Iskandar Muda (g) a) Nursing program, Faculty of Medicine, Mulawarman University, Jalan Krayan Gn. Kelua, Samarinda, Indonesia, mayusef[at]fk.umul.ac.id b) Departement Public Health, Faculty of Medicine, Mulawarman University, Jalan Krayan Gn. Kelua, Samarinda, Indonesia, r.bakhtiar[at]fk.unmul.ac.id c) Nursing program, Faculty of Medicine, Mulawarman University, Jalan Krayan Gn. Kelua, Samarinda, Indonesia, d) Nursing program, Faculty of Medicine, Mulawarman University, Jalan Krayan Gn. Kelua, Samarinda, Indonesia, e) Nursing program, Faculty of Medicine, Mulawarman University, Jalan Krayan Gn. Kelua, Samarinda, Indonesia, f) Departement Internal Medicine, Faculty of Medicine, Mulawarman University, Jalan Krayan Gn. Kelua, Samarinda, Indonesia, yulianakaltim[at]gmail.com g) Nursing program, Faculty of Medicine, Mulawarman University, Jalan Krayan Gn. Kelua, Samarinda, Indonesia, Abstract Background: Peripheral Diabetic Neuropathy (PDN) is a common complication of diabetes with a risk of impaired skin integrity. The main clinical symptom is loss of pain and temperature sensation. Current PDN diagnostic modalities include monofilament, nerve conduction tests, muscle response tests, autonomic tests, sensory vibration tests, and sensory temperature changes. Currently, the temperature sensation test used is the TiP Therm. However, it could not quantitatively measure the temperature felt by PDN patients, while the degree of heat is essential to assess the risks of PDN. Purpose: This study aimed to develop a prototype diagnostic tool to quantitively determine the patient^s temperature threshold. Using thermal stimulation, our portable device could assist screening for the risk of skin integrity damage in PDN patients. Methods: The research was divided into prototype development of E Skin Diabetic Simple Test (E-SDST)) and testing. We designed and formulated the tool components, followed by creating the temperature sensation test tool for the soles. Finally, the device was tested on healthy volunteers. Results: The prototype, consisting of an AC source, temperature controller, temperature sensor, and probe, was calibrated. When tested on 12 healthy volunteers, we found that the average threshold of temperature felt on the soles of the feet was 44 C. Conclusion: This tool provided a quantitative measurement to determine the temperature threshold. Our prototype is portable, user-friendly, easy, and practical. Furthermore, the E-SDST will be tested on larger subjects with PDN to determines the degree of mild, moderate, and severe PDN. Keywords: Diabetic peripheral neuropathy- Neuropathy diagnostic tool- damage to skin integrity Share Link | Plain Format | Corresponding Author (Mayusef Sukmana)

3	Advanced health technology and medical treatment	ABS-25
The Relationship between Accessibility of Telemedicine Services and Decisions on Use: A Cross-Sectional Study among Patient at X General Hospital, Malang Jennyla Puspitaning Ayu1*, Ida Herwati2 Department of Hospital Administration, Sekolah Tinggi Ilmu Kesehatan Kepanjen Abstract Background: One of the accessibility of telemedicine services is the ease of talking with telemedicine service providers and the accuracy of diagnosis. In a study conducted at Outpatient Hospital X, Malang Regency, it was found that as many as 65% of patients interviewed about the use of telemedicine admitted that they only knew about telemedicine services, for example Halodoc, Alodokter, Klikdokter and telemedicine applications that had been provided by the hospital, but had never used them directly. The patient admits that the application menu service in several telemedicine services is too complicated and not easy to use, especially for patients over the age of 45 years Purpose: The purpose of this study was to determine the relationship between the accessibility of telemedicine service applications and the decision to use telemedicine service applications. Methods: The design of this study was a cross-sectional study. This research was conducted in January 2023 at the Outpatient Installation of one of the hospitals in Malang Regency. The total sample for this study was 67 patients. The data were collected using a questionnaire method with Linkert scale about accessibility of telemedicine and decisions on use telemedicine. Statistical analyses were conducted using product moment correlation. Results: The result showed that a significant relationship between the accessibility of telemedicine services and the use of telemedicine services. The significance is 0.000, because the significance is >0.05 then hypothesis is accepted. Conclusion: The ease of talking to health care providers, the ease of hearing the voice of health service providers, the provision of diagnoses according to the patient^s condition, the patient can see clearly the health care provider or health worker, the patient is easy to use the telemedicine application affects the decision to use the telemedicine application in outpatient care Hospital X Malang Regency. Keywords: Telemedicine, accessibility Share Link | Plain Format | Corresponding Author (Jennyla Puspitaning Ayu)

4	Advanced health technology and medical treatment	ABS-101
Modification of Bag Valve Mask based on Bibliometric Review and Analysis : Novelty of Bag Valve Mask Pratama Yulianto (a*), Saryono (b), Latifah Jehloh (c) a) Master of Nursing Student, Jenderal Soedirman University, Purwokerto 53123, Indonesia *pratamayulianto1805[at]gmail.com b)Nursing Departement, Jenderal Soedirman University, Purwokerto 53123, Indonesia c) Nursing Departement, Princes Naradiwas University, Thailand Abstract Background : A Bag Valve Mask (BVM) is a tool for providing Basic Life Support measures in the aspect of ventilation assistance. The effectiveness of providing ventilation assistance can be influenced by the accuracy of the timing of ventilation to minimize the risk of hyperventilation Purpose : The study is intended to analyze current research themes and trends in relation to the global use and adaptation of BVMs Methods : The method used in this research is a descriptive analysis design with a bibliometric analysis approach through the Publish or Perish and VosViewer applications. The article search period used was 2000-2023 from the Scopus and PubMed databases, and continued with a trend analysis of the topics studied Results : The results of article searches that have been carried out on the Publish or Perish application, obtained 193 articles that discuss BVM since 2000-2023 based on the Scopus and Pubmed databases. There are 3 clusters of research topics, namely comparison of the use of BVM with other tools in the ventilation or oxygenation process, the use of BVM in the intubation or induction process, and research related to the effectiveness of BVM tools modified with different techniques or shapes Conclusion : According to the results of bibliometric analysis, there are 193 articles related to the topic of BVM. Currently, research on BVMs consists of comparison, effectiveness of use, and process actions that involve BVMs. However, no research has been conducted on BVM modification. Keywords: Bag Valve Mask, Bibliometric, BVM Share Link | Plain Format | Corresponding Author (Pratama Yulianto)

5	Advanced health technology and medical treatment	ABS-115
Effectiveness of Android-Based Game Therapy on Cognitive Status, Depression, Muscle Strength, and Heart Rate in the Elderly: Pilot Study Citra Windani Mambang Sari1, Hartiah Haroen1, Sheizi Prista Sari1, Husneni Mukhtar2, Nadirawati3, Mochamad Budi Santoso3 1Community Health Nursing Department, Faculty of Nursing, Universitas Padjadjaran 2Electric Engineering, Telkom University 3 Faculty of Health Sciences and Technology, Universitas Jenderal Achmad Yani Abstract Many physical and psychological changes occur in older people. One way to improve cognitive and psychological function in older people is with game therapy. This research aims to identify the effect of Android-based game therapy on older people in enhancing cognitive abilities, reducing depression and increasing muscle strength and heart rate in older people in one of the nursing homes in West Java. This research will use quantitative descriptive methods. The population in this study were older adults living in nursing homes, and sampling was taken using purposive sampling. The criteria used are older adults with a medium MMSE category. Measurements were taken before and after the Android-based game therapy intervention. The types of game therapy used are Tetris Amazing, Flip Memory, and Solve IT, which alternate ten days apart and are given for 30 days by nurses at the nursing homes. Cognitive status using MMSE and EEG. Depression was measured using GDS and GSR. They measured muscle strength using EMG and heart rate using a heart rate measuring device. Data analysis was carried out on univariate and bivariate data. The results of this research are that game therapy can improve cognitive function and reduce depression in older people. The development of Android-based game therapy is needed as a nursing intervention to improve cognitive function in older people living in institutions. Keywords: elderly, cognitive, games, sensors, depression Share Link | Plain Format | Corresponding Author (Citra Windani Mambang Sari)

6	Advanced health technology and medical treatment	ABS-138
Ramut Bot Development to Assist Nurses in Nursing Care Planning Hasby Pri Choiruna Department of Nursing, Universitas Jenderal Soedirman, Indonesia Abstract Background : Nursing planning is a very important nursing process. The nurse must determine the nursing diagnosis, nursing outcomes, and nursing interventions in this nursing planning. The majority of Indonesian nurses plan nursing care conventionally. Nurses who use nursing care books need a relatively long time to plan nursing care, while nurses who do not use books will increase the risk of errors in determining outcomes and nursing interventions. Hospital information and management systems can only be used locally. Online information about nursing diagnoses, nursing outcomes, and nursing interventions is still fragmentary and not yet connected into a nursing plan. There are no online services that can assist nurses to plan nursing care more quickly and precisely. Purpose : The purpose of this study was to develop a bot to assist nurses in planning nursing care. Methods : The design of this study was a waterfall method which consists of communication, planning, modeling, construction, and deployment. Results : The results showed that Ramut Bot (https://t.me/ramutbot) was built on the Telegram platform with BotFather and Manybot. Conclusion : Ramut Bot can be used by nurses anywhere and at any time to plan nursing care so that nurses can determine nursing outcomes and interventions more quickly and precisely according to Indonesian standards. Keywords: Bot, Telegram, nurse, nursing care Share Link | Plain Format | Corresponding Author (Hasby Pri Choiruna)

7	Advanced health technology and medical treatment	ABS-160
Analyzing Galangins Role in Colorectal Cancer through Bioinformatics and Molecular Docking Wening Etikawati Pramana (a), Nur Amalia Choironi (b), Sarmoko (c), M. Salman Fareza (a*) a) Department of Pharmacy, Universitas Jenderal Soedirman, Indonesia b) Department of Pharmacy, Institut Teknologi Sumatera, South Lampung, Indonesia Abstract Background: Colorectal cancer treatment such as limited drug solubility, drug resistance, and non-specific drug targeting. Therefore, there is a need to explore potential compounds with anticancer properties. Galangin has demonstrated its anticancer effects in colorectal cancer cell lines HCT 15 and HT 29 through an in vitro testing. Purpose: This study aims to identify molecular targets, energy, and bonding types of galangin to protein target in colorectal cancer. Methods: Target genes were searched using NCBI, STITCH, STRING, Pubchem and PDB. Direct target and indirect target proteins form the databased were compared with genes associated with colorectal cancer. Using Cytoscape, we identified the top 10 hub genes for molecular docking. Molecular docking validation was performed using PyMOL to determine the root mean square deviation (RMSD), and Autodock Vina was used to calculate bond energy. The results were visualized with Biovia. Results: The potential targets of galangin in colorectal cancer include AKT1, VEGFA, FN1, CYP1A1, MMP2, CYP1A2, SRC, STAT3, TGFB1, and HGF. Among these, AKT1 and SRC are potential proteins for docking, with RMSD values below 2A. Docking analysis indicated that SRC is a promising target for galangin, as it exhibited lower binding energy (-8,4 kcal mol) compared to the positive control. The interaction was observed to bind to the amino acid residue Lys295. Conclusion: Galangin shows potential as anticancer for colorectal cancer by targeting the SRC protein. Keywords: colorectal cancer, galangin, anticancer, bioinformatic, molecular docking Share Link | Plain Format | Corresponding Author (Wening Etikawati Pramana)

8	Biomedical sciences	ABS-8
The potential use of miRNA technology in thalassemia therapy Lantip Rujito, Tirta Wardana Faculty of Medicine, Universitas Jenderal Soedirman Abstract Thalassemias encompass a group of inherited hemoglobin disorders characterized by reduced or absent production of the &#945-- or &#946--globin chains, leading to anemia and other complications. Current management relies on lifelong blood transfusions and iron chelation, which is burdensome for patients. This review summarizes the emerging therapeutic potential of modulating microRNAs (miRNAs) to treat thalassemia. miRNAs are small non-coding RNAs that negatively regulate gene expression through sequence-specific binding to messenger RNAs. Many miRNAs are now recognized as critical regulators of erythropoiesis and are abnormally expressed in &#946--thalassemia. Therapeutically restoring levels of deficient miRNAs or inhibiting overexpression through miRNA mimics or inhibitors/antimiRs, respectively, has shown preclinical efficacy in ameliorating thalassemic phenotypes. The miR-144/451 cluster is especially compelling for targeted upregulation to reactivate fetal hemoglobin synthesis. Advances in delivery systems are addressing previous challenges in stability and targeting of miRNA-based drugs. While still early, gene therapy studies suggest combinatorial approaches with miRNA modulation may provide synergistic benefits. Several key considerations remain including enhancing delivery, minimizing off-target effects, and demonstrating long-term safety and efficacy. While no miRNA therapies have yet progressed to clinical testing for thalassemia specifically, important lessons are being learned through trials for other indications. If limitations can be overcome through multi-disciplinary collaboration, miRNAs hold great promise to expand and transform treatment options for thalassemia in the future by precisely targeting pathogenic molecular networks. Ongoing innovation continues to drive progress in this emerging field towards realizing the clinical potential of miRNA-based medicines for thalassemia patients Keywords: Thalassemia, Gene Therapy, miRNA Share Link | Plain Format | Corresponding Author (Lantip Rujito)

9	Clinical pharmacy	ABS-2
Study of Potential Drug Interactions of Antibiotic Levofloxacin In Covid-19 Patients In Banyumas Regional General Hospital Heny EKowati*, Yufri Mualik, Nialiana Endah Endriastuti Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University Abstract Keywords: COVID-19, drug interaction, Levofloxacin Share Link | Plain Format | Corresponding Author (Heny Ekowati)

10	Clinical pharmacy	ABS-69
The Assessment of Health-related Quality of Life in Women with Breast Cancer Dewi Latifatul Ilma1*, Masita Wulandari Suryoputri1, Rofiqoh Noor Aisyiyah1, Nialiana Endah Endriastuti1 Department of Pharmacy, Universitas Jenderal Soedirman, Indonesia Abstract Background: In 2020, breast cancer caused 30,8% of new cases of cancer among women in Indonesia, making it the highest cause of cancer in women. As the disease progress, health-related quality of life (HRQOL) is a major concern of patients. Purpose: This study aimed to assess HRQOL in women with breast cancer. Methods: We conducted a cross-sectional study in women with breast cancer. The Functional Assessment of Cancer Therapy-General (FACT-G) survey was used to assess the HRQOL of patients. FACT-G questionnaire measure four domains of HRQOL in cancer patients: physical, social/family, emotional, and functional well-being. The inclusion criteria were patients aged 18 years old with the diagnosis of breast cancer and had complete medical records (duration of cancer, chemotherapy cycles, number of chemotherapy drugs, and known history of breast surgery). Results: A total of 70 patients were included in this study. The result showed that mean total FACT-G score was 55.46. For each domain, the mean score of physical well-being (PWB) was 7.07, social/family well-being (SFWB) was 23.71, emotional well-being (EWB) was 5.63, and functional well-being (FWB) was 19.04. Conclusion: Patients had poorer score in emotional well-being and higher ones in the social/family well-being domain. Keywords: breast cancer, health-related quality of life, FACT-G Share Link | Plain Format | Corresponding Author (Dewi Latifatul Ilma)

11	Clinical pharmacy	ABS-102
The Effect of Chemotherapy on Anemia Parameters in Breast Cancer Patients Masita Wulandari S, Nialiana Endah E, Dewi latifatul Ilma, Rani Laelani Department of Pharmacy, Faculty of Health Sciences, Jenderal Soedirman University Abstract Background: Breast cancer is a global health problem. Breast cancer is the highest type of cancer in Indonesia, around 16.6% of 396,914 cases. Breast cancer treatment can be done with chemotherapy. However, chemotherapy can cause side effects, one of which is anemia. These side effects can hinder therapy and even cause death, so it is necessary to monitor the side effects of anemia based on the parameters of hemoglobin (Hb), corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) in breast cancer patients. Objective: determine the effect of chemotherapy drugs on anemia parameters seen from the Hb, MCV, MCHC, and MCH values. Methods: This observational descriptive-analytic study used medical records and interviews conducted over a 2-month period. Purposive sampling was used to select 97 respondents who met the inclusion and exclusion criteria. Anemia parameters (Hb, MCV, MCH, and MCHC) before and after chemotherapy were analyzed using the Wilcoxon and t-tests. Results: The results showed that most patients diagnosed with breast cancer were aged 45-55 years. On average, most patients are undergoing the second cycle of chemotherapy. The most widely used drug is the doxorubicin-cyclophosphamide combination regimen. Based on the results of the analysis using the T test, it was found that chemotherapy drugs had an effect on Hb values (p < 0.05), and the results of the Wilcoxon test analysis found that chemotherapy drugs had an effect on MCHC values (p < 0.05) and MCH (p < 0.05), while the Wilcoxon test results showed that chemotherapy drugs had no effect on the MCV value (p > 0.05). Conclusion: Chemotherapy can significantly affect anemia parameters such as Hb, MCH, and MCHC values. Keywords: anemia, breast cancer, chemotherapy Share Link | Plain Format | Corresponding Author (Masita Wulandari Suryoputri)

12	Clinical pharmacy	ABS-159
THE EVALUATION OF CHEMOTHERAPY ADVERSE DRUG EFFECTS IN CA MAMMAE AT TERTIARY CARE HOSPITAL Nialiana Endah Endriastuti, Masita Wulandari Suryoputri, Dewi Latifatul Ilma, Rani Laelani Department of Pharmacy, Jenderal Soedirman University Abstract Background : Cancer is one of the world^s major health issues. Ca Mammae has the highest incidence in Indonesia (16.6%) out of a total of 396.914 cases. Indonesia has the highest Ca Mammae death rate in 2020, with 234.511 cases (9.6%). In addition to eliminating cancer cells, chemotherapy might damage normal cells and cause adverse effects. The goal of this study is to identify the patterns of chemotherapy drug usage in breast cancer patients as well as the occurrence of chemotherapy medication side effects in patients. Purpose : This study aimed to know the profile of chemotherapy drugs used in Ca Mammae and find out the side effects of chemotherapy medications in Ca Mammae based on the Naranjo algorithm. Methods : This research was a descriptive observational study with purposive sampling. Adverse drug effects was analized from medical record with Naranjo algorithm from May to June 2023. Results : Total of 97 patients with ca mammae who received chemotherapy were women aged 45-59 years (n=53- 54.64%), with the most common chemotherapeutic cycle stages in cycle 2 (n = 27- 27.84%). The profile of Chemotherapy had the following adverse effects: nausea (83.51%), hair loss (86.60%), vomiting (44.33%), peripheral neuropathy (31.96%), low Haemoglobin (26.80%), and nail color changes (23.71%). The Naranjo algorithm produced the majority of Adverse drug effects was a high probability score (n=60- 61.86%). Conclusion: All patients with chemotherapy had adverse drug effects in the high probability category. Keywords: adverse drug, chemotherapy, ca mammae Share Link | Plain Format | Corresponding Author (NIALIANA ENDAH ENDRIASTUTI)

13	Communicable and non communicable disease	ABS-49
Changes in Components of Metabolic Syndrome on Health-Related Quality of Life in Adults in Bogor City Titi Indriyati1, Asri C. Adisasmita2, Mardiati Nadjib2, Ratna Djuwita Hatma2, Imam Subekti3, Soewarta Kosen4, Woro Riyadina5, Telly Purnamasari5 1Fakultas Kesehatan Universitas Mohammad Husni Thamrin 2Fakultas Kesehatan Masyarakat Universitas Indonesia 3Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo 4Kementerian Kesehatan Republik Indonesia 5Badan Riset dan Inovasi Nasional (BRIN) Abstract Background: Metabolic syndrome (MS) is a chronic clinical condition, where each component can change and affect quality of life. Purpose: This study aims to assess changes in the components of metabolic syndrome on health-related quality of life. Methods: The study approach uses a follow-up prevalence design as a cross-sectional derivative of the main cohort study. The diagnosis of MS was the number of criteria for MS is more than 3 out of 5 components using data from a cohort study of NCD risk factors by the Research and Development Center of the Ministry of Health of the Republic of Indonesia in Central Bogor District. Changes in MS components are seen in three monitoring times. Period 1 in 2011/2012, period 2 in 2013/2014, and period 3 in 2017/2018. The HRQoL interview was conducted in 2021 with 874 respondents using the EQ-5D-5L questionnaire. Results: The components of MS in the third monitoring period were: central obesity in men 23.2%- women 78.6%- low HDL levels in men 31%- women 36.4%- hypertension 35.5%- high triglycerides >150 mg/dl 21.9%- fasting blood sugar >100 mg/dl is 38.2%. The component of MS associated with low quality of life below the mean EQ-VAS for Indonesians is central obesity in women, POR (95% CI) = 2.3 (0.9 - 5.4), FBS level <100 mg/dl with a POR (95% CI) = 1.8 (1.1-2.9). HRQoL in a low health profile is in the dimensions of limited mobility, self-care, daily activities, and discomfort/pain, and these problems are most affected by central obesity, hypertension, and FBS levels >100 mg /dl. Whereas on the dimensions of anxiety or depression, it was only affected by hypertension (POR = 1.8 [1.1-2.9]). Conclusion: Hypertension is most associated with low HRQoL in the EQ-5D health profile. Developing more proactive health and Germas intervention programs in the community is necessary. Keywords: changes, components, metabolic syndrome, health-related quality of life, EQ-5D Share Link | Plain Format | Corresponding Author (Titi Indriyati)

14	Communicable and non communicable disease	ABS-74
ANALYSIS RISK FACTORS THAT AFFECTING THE INCIDENCE OF ANEMIA TO FARMERS IN LINGGASARI VILLAGE, BANYUMAS REGENCY Radi, Dwi Sarwani Sri Rejeki, Devi Octaviana Jenderal Soedirman University Abstract Background: Farmers anemia become a problem in various countries including Indonesia considering that the majority of the Indonesian population works in the agricultural sector. Indonesian Ministry of Health shows the prevalence of anemia in Indonesia is estimated at 28.5% in 2020. The incidence of anemia in farmer can decreasing work productivity and can reduce welfare. Unfortunately, data on the incidence of anemia in farmers has not been well documented so there is no strong data used as a basis for policy making. Purpose: The purpose of this study to determine risk factor of anemia in Linggasari Village with analysis the effect of income, education, length of work, history of pesticide exposure, nutrient intake, personal protective equipment (PPE) and helminthic infection. Methods: The design this study was a case control study. Respondent in this research consist of 16 farmers with anemia and 57 farmers without anemia using fix disease sampling. The instruments used questionnaires and examining floating method. Statistic analysis using logistic regression enter method. Result: Personal protective equipment (PPE) has significant effect with farmer anemia (p value 0.023 OR 4.817). The research show farmers who do not use complete personal protective equipment (PPE) have risk five time greater for anemia. The variables that did not affect were education, income, service period, history of exposure to pesticide, nutrient intake and helminthic infection. Conclusion: There is relation between personal protective equipment (PPE) with farmer anemia. This study recommends the farmers to take complete PPE when was working in the field to minimize exposure of chemical and biological agent cause anemia. Keywords: Anemia, risk factors, farmers Share Link | Plain Format | Corresponding Author (Radi SKM )

15	Communicable and non communicable disease	ABS-79
An Analysis of Determinants Affecting Drug Supervisory Performance in Tuberculosis Patients Management in Tasikmalaya, Indonesia Endang Puji Astuti, Mutiara Widawati, Tri Wahono, Yuneu Yuliasih, Wawan Ridwan, Lukman Hakim, Mara Ipa 1) Research Center for Public Health and Nutrition, National Research and Innovation Agency, Cibinong, West Java, Indonesia 2) Student at Faculty of Medicine, Public Health and Nursing (FK-KMK), Gadjah Mada University, Yogyakarta Abstract Background: Early detection and management of Tuberculosis (TB) cases by a trained and experienced Drug Supervisor are crucial in improving drug adherence, achieving TB therapy, and preventing TB transmission. A companion^s comprehension and aptitude are essential to improve the success rate of treating TB patients. However, assistants and health professionals continue to have gaps in their knowledge and comprehension. Purpose: The purpose of this study was to identify the factors that influence the performance of DS in Tasikmalaya. Methods: A cross-sectional survey was carried out in Tasikmalaya from June to August 2021. Individuals who have cared for or are actively caring for TB patients from 2019 to August 2021 are required to be medication supervisors. A systematic questionnaire was used to interview 121 samples from the family and health cadres. A detailed description of drug supervisors^ sociodemographic characteristics, the history of monitored TB patients, knowledge, attitude, and practice toward TB. Statistical studies were performed using logistic regression to identify the risk factors related with the drug supervisor^s drug taking control practice. The odds ratio and 95% confidence interval (CI) are reported. SPSS version 17.0 was used for statistical analysis. Results: The study^s findings show that DS awareness remains insufficient, with only 1.1% of families having enough information. When it comes to attitudes related to managing the patient^s medication consumption, none of the cadres match the requirements for insufficient performance. While most families continue to fall short in practice, cadres have excelled in taking medication, supervising patient re-visits, communicating side effects, inspiring and motivating TB patients, and reporting to local health officials. The final multivariable logistic regression model revealed that males were less likely to practice (aOR 0.165- 95% CI 0.03-0.84, p<0.005). Patients were better accompanied by the designated DS than by those who applied themselves (aOR 0.314- 95% CI 0.13-0.76, p<0.01). None of the other qualities were associated with the practice of completing the DS function. Conclusion: The capacity to carry out their duties effectively and improve TB patient treatment results is required of the DS. In order for DSs to accomplish their tasks, they must continually improve their capability. This includes educating the population on good TB care procedures, particularly for TB patients and their families. Keywords: Drug Supervisor, Knowledge, Performance, Tuberculosis Share Link | Plain Format | Corresponding Author (Endang Puji Astuti)

16	Communicable and non communicable disease	ABS-105
Mapping and Clustering COVID-19 in Kudus District Dyah Retno Safitri1, Dwi Sarwani Sri Rejeki1, Sri Nurlaela1, Rosita Dwi Jayanti1 1Department of Public Health Faculty of Health Sciences Universitas Jenderal Soedirman, Indonesia Abstract Background: Kudus District contributed many confirmed cases of coronavirus disease 2019 (COVID-19) (3,567 cases) with the high case fatality rate (10%) at the end of 2020 in Central Java Province, one of the provinces which was the center of COVID-19 transmission in Indonesia. Spatial analysis is useful for identifying areas of grouping or clusters of cases that indicate high risk areas so that prevention measures can be developed specifically in those areas. This study aimed to map and identify clusters of COVID-19 cases in Kudus District. Methods: An observational method with a case study design was conducted involving all confirmed cases of COVID-19 for the period January-April 2021 in Kota Subdistrict, which was the epicenter of COVID-19 in Kudus District, totaling 257 cases. Spatial analysis included overlay and buffering processed using ArcGIS, and clustering processed using SaTScan. Results: The study results showed that cases tended to be spread evenly in all villages, the most cases (8.2%) are in Mlati Norowito Village. The results of spatial analysis showed that the majority of cases were in villages with a population density of 8001-12,000 people/km2 (51.7%) and villages with a number of social assistance recipients of 801-1200 people (36.6%), residing less than 250 m from health care facilities (50.5%) and less than 250 m from public facilities (59.14%), and 4 secondary clusters of COVID-19 cases were identified. Conclusions: More cases of COVID-19 were found in villages that had a high population density, a large number of social assistance recipients, lived close to health care facilities and public facilities, and 4 secondary clusters were identified. Keywords: Coronavirus disease 2019- Spatial- Clustering- Kudus District Share Link | Plain Format | Corresponding Author (Dwi Rejeki)

17	Communicable and non communicable disease	ABS-111
The Human Schistosomiasis and Soil Transmitted Helminths Infection in North Lore, Poso District, Central Sulawesi, Indonesia 2022 Anis Nurwidayati(a,b*), Gunawan (a,c) Hari Purwanto (d**), Triwibowo Ambar Garjito (a***), Raden Roro Upiek Ngesti Wibawaning Astuti (e****), Opyn Mananta (f), Abdul Rauf (g) a) Research Centre of Public Health and Nutrition, National Research and Innovation Agency Republic of Indonesia (BRIN), Cibinong, West Java, Indonesia b) Doctoral Program Student of Entomology, Faculty of Biology, Gadjah Mada University, Yogyakarta *anisnurw21[at]gmail.com Jl. Teknika Selatan, Sekip Utara Bulaksumur Yogyakarta, Indonesia 55281 c) Doctoral Program Student of Veterinary Medicine, Faculty of Veterinary Medicine, Gadjah Mada University, Yogyakarta Jl. Fauna No.2, Karang Gayam, Caturtunggal, Kec. Depok, Kabupaten Sleman, Daerah Istimewa Yogyakarta 55281 d) Laboratory of Entomology, Faculty of Biology, Gadjah Mada University, Yogyakarta Jl. Teknika Selatan, Sekip Utara Bulaksumur Yogyakarta, Indonesia 55281 e) Parasitology Division Laboratory of Animal Systematic, Faculty of Biology, Gadjah Mada University, Yogyakarta Jl. Teknika Selatan, Sekip Utara Bulaksumur Yogyakarta, Indonesia 55281 f) Poso Regency Health Office Jl. Pulau Timor No.3, Gebang Rejo, Kec. Poso Kota, Kabupaten Poso, Central Sulawesi 94612 g) Central Sulawesi Province Health Office Jl. R.A. Kartini No.11, Lolu Utara, Palu Selatan, Kota Palu, Central Sulawesi Corresponding Author: *Anis Nurwidayati (anisnurw21[at]gmail.com) ** Hari Purwanto (Hari.purwanto[at]ugm.ac.id) ***Triwibowo Ambar Garjito (triwibowoa[at]gmail.com) ****Raden Roro Upiek Ngesti Wibawaning Astuti (upiekastuti[at]ugm.ac.id) Abstract Background: Schistosomiasis in Indonesia is caused by Schistosoma japonicum, with the intermediate host being the snail Oncomelania hupensis lindoensis. In Indonesia, it is distributed in three endemic areas only: Napu and Bada Highlands of Poso Regency and Lindu Highland of Sigi Regency, Sulawesi Tengah Province. Soil-transmitted helminths infection often occurred with the schistosomiasis infection. It caused by round worm, Ascaris sp., Trichuris trichiura, and also hookworm. Purpose: This study aimed to determine the prevalence of human schistosomiasis and soil-transmitted helminth infection in North Lore, Poso District, Central Sulawesi. Methods: The prevalence of schistosomiasis in humans in 2022 was obtained from the Schistosomiasis Laboratory in Napu, North Lore. A stool survey was conducted in seven endemic villages of North Lore, on all residents aged over two years. The stool samples were collected from 8.807 people in North Lore, Poso District, Central Sulawesi Province. Stools were examined using the kato-katz examination technique. Results: The result showed that the stool coverage was 80.55%. The prevalence of human schistosomiasis in North Lore was 1.45%, and the prevalence of Ascariasis, hookworm, and Trichuris trichiura respectively were 2.04%, 0,83%, and 0,08%. Conclusion: The human schistosomiasis infection was still found, it indicated that the transmission is still occurring. This study recommends to give health promotion more intensively, especially in using personal protection to prevent schistosomiasis infection Keywords: Schistosomiasis- Schistosoma japonicum- Soil Transmitted Helminth- Ascaris, Hookworm- Trichuris trichiura Share Link | Plain Format | Corresponding Author (Anis Nurwidayati)

18	Communicable and non communicable disease	ABS-113
Increasing Age Increases the Occurrence of Urinary Incontinence at the Jakarta Nursing Home Nurul Fatin1, Etty Rekawati2, Dwi Nurviyandari2, Widyatuti2, Wang Jing-Jy3, Winda Eriska2, Utami Rachmawati2 1Undergraduate Study Program, Faculty of Nursing, Universitas Indonesia 2Department of Community Nursing, Faculty of Nursing, Universitas Indonesia, JL. Prof. Dr. Bahder Djohan, Depok, West Java - 16424 3National Cheng Kung University College of Medicine Abstract Objective: The elderly is a designation given to one with a life span of more than 60 years. In the elderly, there are many deteriorations of systems within the body, one of which is the urinary system. Urinary incontinence is one of the health problems associated with the urinary system and is often reported in the elderly. As the number of older people in the world grows, health problems associated with them also increase, one of which is urinary incontinence. The average prevalence of urinary incontinence in the world is 25-45%, and in Indonesia alone, the rate is up to 11.6%, with an average age of 51 years. Method: The study uses a cross-sectional design in the elderly population in several nursing homes in Jakarta. The method used for sampling is non-random sampling with a purposive sampling technique. By calculating the number of samples using the estimate of cross-sectional proportionality from a total population of 1,097 elderly in nursing homes, we obtained a sample of 317 people. The inclusion and exclusion criteria for the research are the elderly who can communicate well and the elderly who withdrew participation while the study was ongoing, respectively. Results: Based on the results of the chi-square test, it was found that there was a link between age and the incidence of urinary incontinence in the Jakarta nursing home residents, with a p-value of 0.033. This result indicates a statistically significant relationship between age and the incidence of urinary incontinence. Based on a univariant analysis of frequency distribution, the percentage of urinary incontinence incidents in young elderly (60-74 years) was 27%, elderly (75-90 years) was 28%, and senior elderly (>90 years) was 80%. Conclusions: Based on the results of these data analyses, it is concluded that there are positive relationships between age and the incidence of urinary incontinence, in which the higher the number of senior elderly, the higher the incidence of urinary incontinence. The results of this study suggest that the older a person is, the greater the risk of urinary incontinence. Keywords: Elderly, Age, Urinary Incontinence, Nursing Home Share Link | Plain Format | Corresponding Author (Nurul Fatin)

19	Communicable and non communicable disease	ABS-128
COMPREHENSIVE KNOWLEDGE AND ACCESS TO INFORMATION ABOUT HIV AIDS AMONG ADOLESCENTS IN RURAL AREAS Lu^lu Nafisah, Yuditha Nindya Kartika Rizqi, Aisyah Apriliciciliana Aryani Department of Public Health, Faculty of Health Sciences, Universitas Jenderal Soedirman Abstract HIV/AIDS is still a problem for public health worldwide, particularly in Indonesia. It appears that little progress has been made to lower the incidence of HIV/AIDS despite increased advocacy and the dissemination of comprehensive HIV/AIDS information in Indonesia. There were 267 new HIV cases discovered in 2020 in Banyumas Regency, 159 AIDS cases and 13 people who died. Young adolescents and teenagers make up an increasing percentage of HIV-positive people globally. Comprehensive knowledge about HIV-AIDS is related to HIV-AIDS prevention behavior among adolescents both in rural and urban areas. This study aimed to describe the comprehensive knowledge of HIV-AIDS among adolescents in rural areas. This study used a descriptive approach and two-stage random sampling. Data was analyzed by univariate analysis. A total of 169 adolescents (15-18 years) participated in this study. All teenagers in this study had heard about HIV-AIDS. Most respondents answered ^false^ to statements about AIDS being curable (56.8%), people infected with HIV always looking unhealthy (44.4%), and the statement that someone could do a test to find out whether he was infected with HIV (90, 5%). This shows that even though teenagers have heard about HIV-AIDS, they are still mistaken or incorrect in answering statements about HIV-AIDS. Furthermore, the majority of respondents stated that there were other diseases that could be transmitted from men or women through sexual intercourse apart from HIV-AIDS (92.9%) and mentioned RSUD as a place for treatment if someone was infected with a sexually transmitted disease (85.8 %). Keywords: Adolescent, Comprehensive Knowledge, HIV-AIDS, Rural Share Link | Plain Format | Corresponding Author (Lulu Nafisah)

20	Communicable and non communicable disease	ABS-129
RELATIONSHIP BETWEEN AGE, KNOWLEDGE AND PERCEIVED STIGMA TOWARD HIV/AIDS AMONG HOUSEWIVES IN GARUT REGENCY Hartiah Haroen 1, Wahyuni Maria Prasetyo Hutomo 2, Ahmad Yamin1, Neti Juniarti1, Citra Windani Mambang Sari1, Witdiawati1 1Community Health Department, Nursing Faculty, Universitas Padjadjaran, Indonesia - 2Master Student, Fakultas Nursing Faculty, Universitas Padjadjaran, Indonesia Abstract There are aprroximately 5,100 new Human Immunodeficiency Virus (HIV) infections in the Housewife (IRT) group every year, and 35% of them are infected from their partners. This rate is higher than HIV cases in other groups such as the MSM (man sex with man). West Java is one of the four provinces with the highest number of HIV/AIDS cases in Indonesia. One of the districts in West Java with a high rate of HIV transmission is Garut Regency, where the estimation of 1,681 people with HIV/AIDS. However, the number of HIV infections detected in January 2023 was only 1,286 cases, so it is estimated that 38% are still undetected. This research was conducted to determine the relationship between Age, knowledge and Perceived stigma about HIV among housewive. This research is quantitative research with a cross sectional approach. Data collection was carried out in May 2023 and was located in X Village, Garut Regency, West Java. The research population was housewives in the category of women of childbearing age (aged 20-49 years) who lived permanently in the sub-district area using a purposive sampling technique of 97 housewives. Data collection was carried out door to door using a questionnaire which included data demographic characteristic, knowledge abot HIV/AID and perceived stigma. Data analysis was carried out using SPSS software (Version 21), frequency distribution analysis and chi-square test. The research results showed that the majority of housewives (64 people, 66.0%) had poor knowledge about HIV, (32.0%) had high stigma about HIV and (34.0%) had low stigma. Meanwhile, only a few (34.0%) of the housewives had good knowledge and (25.8%) the housewives^ stigma about HIV was low. Relationship between domestic workers^ knowledge and stigma about HIV (P<0.021). The majority of housewives in the early adulthood stage (55 people, 56.7%), had high stigma (28.9%) and low stigma (27.8%), low stigma was more often found in late adulthood housewives (53.4%) . Age was related to stigma about HIV (P < 0.014). To increase knowledge about HIV and reduce stigma in society, efforts are being made to increase knowledge and group discussions about HIV/AIDS. Keywords: HIV/AIDS, Housewives, Stigma, Knowledge Share Link | Plain Format | Corresponding Author (Hartiah Haroen)

21	Communicable and non communicable disease	ABS-135
DETERMINANT FACTORS OF BOOSTER COVID-19 VACCINATION PRACTICE IN INDONESIA Laviana Balqies, Siwi Pramatama Mars Wijayanti, Devi Octaviana, Dwi Sarwani Sri Rejeki, Sri Nurlaela, Yuditha Nindya Kartika Rizqi Public Health Department, Faculty of Health Sciences, University of Jenderal Soedirman Abstract During the pandemic, Covid-19 vaccination, particularly booster vaccination, faces many challenges in its implementation in the field. Booster vaccination coverage in Indonesian community has still not reached the target. The aims of this study is to determine the most influential factors on the practice of booster vaccine 1 in Banyumas Regency. This research is a quantitative research with a Cross Sectional approach. This research was conducted in the Banyumas Regency area in April 2023, with total samples 300 respondents. The independent variables of this research are age, gender, education, knowledge, exposure to information, perception of government policy, anxiety about side effects, family support, support from community leaders, support from health workers, perception of booster vaccination 1 and history of comorbid diseases. The dependent variable of this research is the behavior of the COVID-19 booster vaccine. The research instrument used in this research is Google form distribution via social media such as WhatsApp groups. Data analysis carried out by univariate, bivariate with chi square test, and multivariate with logistic regression. The results of the analysis showed that education was the most influential factor with the behavior of the COVID-19 1 booster vaccine, namely education p value 0.000 OR 15,497 Variables that did not affect the behavior of doing COVID-19 booster vaccination were age, gender, knowledge, exposure to information, perceptions of government policies, anxiety about side effects, family support, community leader support, health worker support, perceptions of Booster vaccination 1 and history of comorbid diseases (p value > 0,05) Keywords: Booster vaccination, COVID-19, practice Share Link | Plain Format | Corresponding Author (Siwi Pramatama Mars Wijayanti)

22	Communicable and non communicable disease	ABS-144
COVID-19 Outbreak Investigation of A Tablighi Jamaat Cluster in Gunungkidul District, Yogyakarta Province, Indonesia in The Early COVID-19 Pandemic, May 2020 Rosita Dwi Jayanti1,2*, Riris Andono Ahmad2 1Department of Public Health, Faculty of Health Sciences, Jenderal Soedirman University, Indonesia 2Field Epidemiology Training Program, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Indonesia Corresponding Author: Rosita Dwi Jayanti (rositadwijayanti[at]gmail.com) Abstract Background: On May 1st, 2020, the Tablighi Jamaat (JT) cluster in Gunungkidul District was declared to be one of the major Coronavirus Disease 2019 (COVID-19) clusters in Yogyakarta Province. Purpose: This study aimed to describe the cluster and identify the risk factors. Methods: This study used secondary data from the outbreak investigation report and close contact tracing form in the Gunungkidul District Health Office. A 1:4 case-control study was conducted. Cases were people involved in a JT gathering in Jakarta and close contacts with positive results of reverse transcription-polymerase chain reaction (RT-PCR) or reactive results of antibody rapid test. Controls were those who tested negative RT-PCR or non-reactive antibody rapid test. Multivariate analysis with logistic regression was used to identify risk factors. Results: The index case was a resident of Gunungkidul District who had a history of attending a JT gathering in Jakarta, which resulted in local transmission. A total of 54 cases from 275 who were tested (41 reactive antibody rapid test, 13 positive RT-PCR), one mortality case, identified between April 4th and May 20th, 2020. 50% of cases were 40-59 years old, 53.70% were male, and 87.04% were asymptomatic. The multivariate analysis result showed that chance to find multiple contacts in case group was 5.05 times greater than control group (OR:5,05- 95% CI:1.48-17.15), and chance to find contact of religious activity in case group was 2.19 times greater than control group (OR:2.19- 95% CI:1.08-4.47). Conclusion: The COVID-19 outbreak became a JT cluster because an index case who attended a JT gathering in Jakarta triggered a local transmission. The risk factors were multiple contacts and contact of religious activity. It is necessary to involve religious leaders in contact tracing, initiate health-promoting mosques, and maximize village-level COVID-19 task force to control residents^ mobility when a COVID-19 outbreak occurs. Keywords: COVID-19, Outbreak, Investigation, Cluster, Tablighi Jamaat Share Link | Plain Format | Corresponding Author (Rosita Dwi Jayanti)

23	Communicable and non communicable disease	ABS-151
Risk Factors of Dengue Fever : Systematic Review Rizki Wijayanti Jendral Soedirman University Abstract Dengue Hemorrhagic Fever is a type of arbovirus disease obtained from 2 types of mosquitoes, namely Aedes albopictus and Aedes aegypti where these two types of mosquitoes are important disease problems in almost all countries in the world, especially in countries with warmer climates. However, research on dengue risk factors is still independent in various countries, so it cannot be concluded holistically. Through research design, systematic review is able to summarize and answer the causes of DHF in several countries. This research method is a systematic review with guidelines following the PRISMA Cheklist in 2009. Article search uses 5 keywords dengue hemorrhagic fever, risk factors dengue hemorrhagic fever, dengue fever, risk factors dengue fever, dengue. The search includes all literature published between 2016 - 2022. A total of 221 articles were found using four electronic data bases, namely Google Scholar, PubMed, Science Direct and Scopus. as a search engine with two variations of keywords. However, as many as 189 articles were re-issued due to inappropriate titles and keywords. A full-text assessment was conducted, and as many as 20 were expelled for not meeting the inclusion criteria. Finally, only 12 articles fit the inclusion criteria and content assessment can be carried out. The results of the study found 4 major groups of risk factors that were widely studied, namely sociodemography, place of dwelling, environment and behavior. Sociodemographic factors related to the incidence of DHF are age. Urban areas are the place of dwelling with the most dengue cases. The aspect of the environment that is widely studied is the type of house. The most significant behavioral factor at risk for transmission is PSN (Mosquito Nest Eradication) behavior. Based on systematic reviews, the risk factor that consistently has the highest percentage of significance and the most analyzed of the 10 articles is Environment (37.5%). Keywords: dengue hemorrhagic fever, risk factors dengue hemorrhagic fever, dengue fever, risk factors dengue fever, dengue Share Link | Plain Format | Corresponding Author (Rizki Wijayanti)

24	Communicable and non communicable disease	ABS-152
RISK FACTORS OF COVID-19 TRANSMISSION TO HEALTH WORKERS IN SOUTHEAST ASIA Qonitah Fitri Prathiwi(1)*, Dwi Sarwani Sri Rejeki(2) , Siwi Pratama Mars Wijayanti(3) Master of Public Health, Faculty of Health Sciences Universitas Jenderal Soedirman Abstract The transmission of Covid-19 to health workers is an important issue in the pandemic era. Health workers are the front line in handling Covid-19 so they are very vulnerable to being exposed to and even contracting Covid-19 disease. It is necessary to conduct an assessment of the factors that influence the transmission of Covid-19 to health workers, especially in the Southeast Asian Region. The aim of the systematic review is to examine the factors that influence the transmission of Covid-19 cases to health workers in Southeast Asia. The research journal database was retrieved by accessing PubMed and Google Scholar, and using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) method using the keywords ^risk factors^ AND ^transmission^ AND ^Covid-19^ AND ^health workers^. After going through a series of selections, 11 research journals were obtained that were published in 2020-2023 and were considered relevant for study. Based on the results and discussion of the systematic review, it is known that the factors that influence the transmission of Covid-19 to health workers in Southeast Asia are: average age, type of profession, comorbid history, travel history, community contact at work, contact with Covid-19 patients, adherence to the use of PPE and implementing health protocols, levels of workload, levels of stress and immunization status of health workers. Keywords: Covid-19, health workers, risk factors, southeast asia Share Link | Plain Format | Corresponding Author (Qonitah Fitri Prathiwi)

25	Communicable and non communicable disease	ABS-167
ANALYSIS FACTORS RELATING TO QUALITY OF LIFE ADOLESCENTS WITH THALASSEMIA IN BANYUMAS Alifka Deti Sri Maharani, Siwi Pramatama Mars Wijayanti, Sri Nurlaela, Dwi Sarwani Sri Rejeki Universitas Jenderal Soedirman Abstract Background: : Quality of life adolescent Thalassemia important to study because it is genetic disease last a lifetime and can cause blood disorders,organs disorders and psychosocial problems. Adolescents are transitional phase where psychosocial needs are very important. This study aims to determine the value of quality of life and factors related to the quality of life of adolescents with thalassemia in Banyumas with the PedsQL instrument. Method: Quantitative analytic with cross-sectional study design. The population was adolescent Thalassemia who resided in Banyumas. Sample of 72 respondents with the total sampling method. Data were collected by visiting the respondent^s house and conducting interviews by filling out questionnaire. Data analysis used SPSS with univariate, bivariate (chi square),and multivariate (logistic regression) statistical analysis. Results: The quality of life of adolescents with thalassemia in Banyumas is classified normal with PedsQL value of 77.16>65.48. There is influence between family support (p=0.043), father^s education (p=0.031), motherl education (p=0.037), family income level (p=0.012), and a history of splenectomy (p=0.010) with the quality of life of adolescents with thalassemia in Banyumas. Concluison: The better family support, father^s education, mother^s education, family income, and not doing splenectomy,the better the quality of life adolescents with thalassemiain Banyumas. Keywords: Thalassemia, Adolescents, PedsQL, Quality of Life Share Link | Plain Format | Corresponding Author (Alifka Deti Sri Maharani)

26	Environmental and occupational health	ABS-10
The Relationship Between Characteristics Of Female Respondents Of Childbearing Age With Hbcore Antibody Titers In Basic Health Research. Noer Endah Pracoyo (1), Felly Philipus Senewe (1), Basuki Rachmat (1), Raras Anasi (2) a) National Research and Inovation Agency. b). Health Policy Agency Abstract The Relationship Between Characteristics Of Female Respondents Of Childbearing Age With Hbcore Antibody Titers In Basic Health Research. by Noer Endah Pracoyo (*a), Felly Philipus Senewe (*a), Basuki Rachmat (*a), Raras Anasi (*2). a) National Research and Inovation Agency. b). Health Policy Agency Abstract Hepatitis B is an infectious disease and is still a public health problem in the world, including in Indonesia. The prevalence of hepatitis B in infants under five years in 2007 was 7.8% and in 2013 was 4.2% (Indonesian Basic Health Research). Hepatitis B can be transmitted vertically and horizontally. Vertical transmission occurs from a mother infected with hepatitis B to her child at birth. The purpose of the study was to determine the presentation of women of childbearing age who suffer hepatitis Bcore and its relationship with risk factors of age, residence, education and occupation. The method used is using secondary data from the Indonesian Basic Health Research in 2013. The data used is data that has been filtered and eligible and can be integrated between biomedical data and public health data. The result obtained is that there is a significant relationship between respondent characteristic data and chronic hepatitis B. The Variable2 on the characteristics of the respondents included the age group < of 17 years and > of 35 years with values (p = 0.000- CI 95% = 1.46-1.73), lower education consists of upper secondary school and below (p = 0.000- CI 95% = 1.35-1.51), Working respondents (p = 0.000- CI95% = 1.12- 1.31) and the respondent^s place in rural A with a value (p = 0.000- CI 95%= 1.45-1. 35). In conclusion, the characteristics of the respondents in the 2013 Indonesian Basic Health Research was a significant relationship with chronic hepatitis B. Key words: Chronic Hepatitis B, Characteristics of respondents, Indonesian Basic Health Research 2013 Keywords: Please Just Try to Submit This Sample Abstract Share Link | Plain Format | Corresponding Author (Noer Endah Pracoyo)

27	Environmental and occupational health	ABS-14
Spatial Autocorrelation of Dengue in Relation to Population Density in Balangan District, South Kalimantan Indonesia: An Ecological Study Muhammad Rasyid Ridha1*, Ririh Yudhastuti2, Norjanah3, Guntur Bagus Pamungkas3, Sri Listyarini3, Untung Norleyandi4 1. Doctoral Program of Public Health, Faculty of Public Health, Universitas Airlangga, Surabaya- 2. Faculty of Public Health, Universitas Airlangga, Surabaya- 3. Urban and Regional Planning Study Program, Faculty of Science and Technology, Universitas Terbuka, Indonesia 4. Balangan Health Office, South Kalimantan Province, Indonesia Abstract Background: Cases of Dengue in Balangan Regency have the 2nd highest Incidence Rate (IR) in South Kalimantan of 126.64 per 100,000 population. Purpose: This study aims to determine distribution patterns and perform spatial analysis of dengue with population density . Methods: Secondary data on dengue cases and population density were analyzed in a time series and Spatial Autocorrelation for 2017-2021 using spatial analysis methods and statistical tests using QGIS 3.22.10, GeoDA version 1.16, and IBM SPSS version 25. Results: Our findings show that high dengue is in areas with high densities. also high. Based on spatial analysis, dengue cases have a positive spatial relationship in 2017-2019 and a negative spatial relationship in 2020-2021, where dengue cases have a distribution pattern that is not clustered (spread). Six villages are categorized as high-high. A simple linear test shows that there is an effect of population density on the incidence of dengue. Conclusion: Monitoring in areas with high population density using spatial analysis is required in early detection and planning activities by the local Health authorities. Keywords: Spatial Autocorrelation, Dengue, Balangan, Overlay Share Link | Plain Format | Corresponding Author (Muhammad Rasyid Ridha)

28	Environmental and occupational health	ABS-60
Environmental Health Risk Assessment (EHRA) Kabupaten Bengkalis Riau Herniwanti1*, Efrina Dewi1,2 1Department of Magister Public Health, Universitas Hang Tuah Pekanbaru, Indonesia 2Department of Public Health Office , Kabupaten Bengkalis, Riau, Indonesia Abstract Background: The EHRA (Environmental Health Risk Assessment) research is a district-wide participatory survey aimed at determining the state of sanitation facilities and community attitudes about hygiene and sanitation at the home level. The EHRA study yielded the Sanitation Risk Index (IRS). Purpose: The EHRA Study sought to provide an overview and information on the circumstances of sanitation facilities, hygiene, and sanitation behavior that represent a health risk in Bengkalis Regency, Riau Province. Methods: The EHRA study was carried out by conducting a survey in all villages in Bengkalis district, beginning in 2021, with the assistance of sanitarians and health cadres, mapping the target survey area, and requiring at least 40 respondents per village and at least 5 respondents per neighborhood unit, with female respondents or girls aged 15-60 years. Results: An overview of the sanitation risk index values that may be drawn from the variables evaluated from Clean and Healthy Behavior, Domestic Wastewater, Garbage, and Water Sources. With an interval of 19.5 between the maximum and minimum total risk indices, they are 304 and 226, respectively. According to these findings, there were 2,600 respondents in the Bengkalis Regency and 155 villages, which fall into a number of categories. There are 78 Villages with a medium risk, 33 Villages with a high risk, and 22 Villages with a very high risk. Conclusion: Conclusions and recommendations regarding EHRA issues in Bengkalis Regency are as follows: Villages at high risk concentrate on addressing the components of residential wastewater, solid waste and standing water, hygiene and sanitation behavior, and PHBS. High-risk villages and sub-districts concentrate on sanitation development in the areas of waste water, solid waste, and standing water. The vulnerable communities and sub-districts are focused on the establishment of clean water sources. Keywords: Environmental Health, Risk Assesment, EHRA, Bengkalis Share Link | Plain Format | Corresponding Author (Herniwanti Herniwanti)

29	Environmental and occupational health	ABS-62
Comparring Reactive Oxygen Species and Superoxide Dismutase 3 of Biosmart and Safe Bus and Reguler Bus Passengers Ai Devi Nuraeni1,a), Awal Prasetyo2, Udadi Sadhana3, Agus Subagio4, Susilo Adi Widyanto5, Arlita Leniseptaria Antari6, Stefan Arman7, Anthony Steven Hambali8, Soerjanto Tjahjono9, Saras Pujowati1, Liftia Layyinatus Syifa1, Muflihatul Muniroh2, Neni Susilaningsih2 1Postgraduate Student - Masters in Biomedical Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia 2Department of Biomedical Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia 3Department of Pathology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia 4Departement of Physics, Faculty of Science and Mathematics, Diponegoro University, Semarang, Indonesia 5Department of Mechanical Engineering, Faculty of Engineering, Diponegoro University, Semarang, Indonesia 6Department of Microbiology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia 7Laksana Karoseri, Semarang, Indonesia 8PO Sumber Alam, Purworejo, Indonesia 9Chairman of Komite Nasional Keselamatan Transportasi (KNKT) Abstract Abstract. Bus are the most popular land transportation among the people. Biosmart and safe bus apply the principle that thebus compartment which is a biological environment must be in a balanced state according to the disease triangle concept that is influenced by the host, in this case is the passenger, the agent causing the infection is a virus and the environment is the roomin the bus cabin. The aim of the present study is to analyze the differences in ROS and SOD3 levels of Biosmart and safe bus passengers and reguler bus passengers. The research is a non-blinded randomized control trial with pre-posttest design. Eighty passengers were randomly separated into two groups. control group 40 uses reguler bus, and intervention group uses Biosmart and safe bus 40. Nasal wash was taken by ENT specialists, and the levels of Sinonasal ROS and SOD3 were interpreted by ELISA. The data were analyzed by using Mann Whitney, Wilcoxon, Independent t-test and Paired t-test. The results showed that the average level of SOD3 in the sample of Biosmart nd safe bus passengers samples were higher than in reguler bus passengers. The difference in ROS levels in the treatment group was lower than in the control group which was stated to have a significant effect with a p value last than 0,001 in both groups. Conclusion Based on the presentatin of the data and discussion in the previous chapter, it can be concluded from this study that there is a statistically significant difference in ROS levels for Biosmart and safe bus passengers after the trip. The passenger group that was given the Biosmart and safe bus treatment showed lower ROS levels compared to the reguler bus and there was also a statistically significant difference in the SOD3 levels of the Biosmart and safe bus passengers after the trip.The Biosmart and safe bus passengers group had higher SOD3 levels compared to the reguler bus. Keywords: ROS, SOD3, Biosmart and Safe Bus, physical distancing, HEPA Filters, Nanosilver, ACHADANA herbal mask, ELISA. Share Link | Plain Format | Corresponding Author (Ai Devi Nuraeni)

30	Environmental and occupational health	ABS-132
Risk factors for allergic rhinitis in wheat flour mill workers in Indonesia Aliefia Ananingrum Dyah Ayu Ramadhani, Nur Ulfah, Suryanto Jenderal Soedirman University Abstract Background: One of the potential hazards in flour mills is wheat dust and flour dust, which are allergens that can trigger symptoms of occupational rhinitis. This study aims to determine the relationship between age, work period, and use of mask with symptoms of occupational allergic rhinitis in flour mill workers. Methods: The type of research used is quantitative with a cross-sectional study design. The population of this study amounted to 138 people with a sample of 103 people. Chi-Square test and multiple logistic regression were used in this study. Results: Age variable (p-value=0.026), work period (p-value=0.006), use of masks (p-value=0.005) has an association with symptoms of occupational allergic rhinitis in wheat flour mill workers. Conclusion: The factor most associated with symptoms of occupational allergic rhinitis is age with an Odds Ratio value of 4.933 so that workers aged <40 years old have a chance of experiencing symptoms of allergic rhinitis 4.933 times greater than workers aged &#8805- 40 years. Suggestion: Education on the prevention of allergic rhinitis symptoms due to work, especially for workers who are aged < 40 years and working period &#8805- 5 years, monitoring the use of masks, the addition of exhaust fans, and the consumption of healthy and nutritious food. Keywords: Allergic Rhinitis Symptoms, Age, Working Period, Mask Usage, Wheat Flour Workers Share Link | Plain Format | Corresponding Author (Aliefia Ananingrum Dyah Ayu Ramadhani)

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