THE EVALUATION OF CHEMOTHERAPY ADVERSE DRUG EFFECTS IN CA MAMMAE AT TERTIARY CARE HOSPITAL Nialiana Endah Endriastuti, Masita Wulandari Suryoputri, Dewi Latifatul Ilma, Rani Laelani
Department of Pharmacy, Jenderal Soedirman University
Abstract
Background : Cancer is one of the world^s major health issues. Ca Mammae has the highest incidence in Indonesia (16.6%) out of a total of 396.914 cases. Indonesia has the highest Ca Mammae death rate in 2020, with 234.511 cases (9.6%). In addition to eliminating cancer cells, chemotherapy might damage normal cells and cause adverse effects. The goal of this study is to identify the patterns of chemotherapy drug usage in breast cancer patients as well as the occurrence of chemotherapy medication side effects in patients.
Purpose : This study aimed to know the profile of chemotherapy drugs used in Ca Mammae and find out the side effects of chemotherapy medications in Ca Mammae based on the Naranjo algorithm.
Methods : This research was a descriptive observational study with purposive sampling. Adverse drug effects was analized from medical record with Naranjo algorithm from May to June 2023.
Results : Total of 97 patients with ca mammae who received chemotherapy were women aged 45-59 years (n=53- 54.64%), with the most common chemotherapeutic cycle stages in cycle 2 (n = 27- 27.84%). The profile of Chemotherapy had the following adverse effects: nausea (83.51%), hair loss (86.60%), vomiting (44.33%), peripheral neuropathy (31.96%), low Haemoglobin (26.80%), and nail color changes (23.71%). The Naranjo algorithm produced the majority of Adverse drug effects was a high probability score (n=60- 61.86%).
Conclusion: All patients with chemotherapy had adverse drug effects in the high probability category.
