Synthesis of Chalcone-Coumarin Hybrid with the Assistance of Ultrasonic Waves and In Silico Test of alpha Glucosidase Enzyme Aldi Dwi Febrianto(a*), Hanhan Dianhar(b), Elsa Vera Nanda(c)
a) Chemistry, Jakarta State University
Jl. Rawamangun Muka, RT.11/RW.14, Rawamangun, Pulo Gadung, Kota Jakarta Timur, DKI Jakarta.
*aldidwi145[at]gmail.com
(b) Faculty of Mathematics and Natural Sciences
Abstract
Type 2 diabetes mellitus is one of the diseases that is quite common in Indonesia, even in the world. Several commercial drugs have been developed, but they cause various side effects that can be detrimental so that research is needed to develop drug candidates from natural compounds. Secondary metabolites such as chalcones and coumarins show interesting bioactivity as antidiabetics, making it possible to form hybrid compounds from chalcones and coumarins to increasing their bioactivity. In addition, hybrid compounds also have the advantage of reducing side effects and overcoming drug resistance compared to their precursor compounds. In this study, nine chalcone-coumarin hybrid compounds were synthesized by ultrasonic method using H2SO4 catalyst and glacial acetic acid solvent. The yield obtained was 31.56 - 83.00% with 3-[(2E)-3-(4- methoxyphenyl)prop-2-enoyl]-8-methoxy-2H-chromen-2-one (B2) receiving the highest yield. The nine hybrid compounds were tested for molecular docking against alpha glucosidase enzyme and it was found that all compounds had good potential as potential agents against diabetes with the compound 3-[(2E)-3-(4- methoxyphenyl)prop-2-enoyl]-7-hydroxy-2H-chromen-2-one (CI) having the highest Gibbs free energy and Ki values, namely -8.53 kcal/mol and 0.56 mikro molar
Keywords: anti-diabetic, type 2 diabetes mellitus, chalcone-coumarin hybrid, ultrasonic.
