Formulation and Physical Evaluation of Lozenge Saga Leaves Extract (Abrus Precatorius L.) With Variations of Sucrose Mannitol as Filler Atika Setyawati, Beti Pudyastuti, Eka Prasasti Nur R.
Jenderal Soedirman University
Abstract
Background: Saga leaves contain alkaloids, flavonoids, and saponins that have antibacterial activity against Staphylococcus aureus, which causes canker sores or infections in the mouth. Lozenge is a possible dosage form that can mask the bitter taste.
Purpose: The aim of this research was to investigate the effects of variations in the ratio of sucrose mannitol on the physical properties of the resulting granules and lozenges.
Methods: Saga leaf Saga leaves extract lozenges were prepared in 3 formulas with sucrose mannitol ratio variations of 1:0, 0.5:0.5, 0:1. The physical properties of the granules were evaluated by organoleptic, moisture content, flow time, angle of repose, tapped density, and size distribution. The physical properties of the lozenges were evaluated by organoleptic, size uniformity, weight uniformity, hardness, friability, and disintegration time.
Results: Moisture content Moisture content of formula I, II and III were in the range 2 to 3%. Granules flow time above 10 grams per second. Granules angle of repose is in the range of 30 to 34. The granules size is 32 to 34% with a mesh size of 30. The compressibility index of the granules were in the range of 11 to 12. The %CV weight uniformity of lozenges were <5%. The lozenges hardness were in the range of 7 to 12 kg. The lozenges friability were in the range of 0.444 to 0.742%. The lozenges disintegration time were in the range of 12 to 17 minutes.
Conclusion: The use of sucrose and mannitol in lozenges formulation significantly affected several physical properties of the granules and lozenges, namely the angle of repose and tablet hardness. The formula III exhibited the best physical properties as shown by statistical analysis.
