REVIEW: CHEMICAL COMPOUNDS IN SAMBILOTO (Andrographis paniculata) AND BIOSYNTHESIS STUDY
Eka Prasasti Nur Rachmani(a*), Yayuk Sri Astuti(a), Puji Lestari(b)

a) Department of Pharmacy, Jenderal Soedirman University, Karangwangkal Purwokerto, Jawa Tengah, Indonesia.
b) Department of Chemistry, Jenderal Soedirman University, Karangwangkal Purwokerto, Jawa Tengah, Indonesia.

Abstract

Sambiloto (Andrographis paniculata) is a plant that has been empirically and chemically proven to have medicinal properties. Its benefits are due to the bioactive compounds contained therein. Identification of plant bioactive compounds is an important aspect in the discovery and development of new drugs. These bioactive compounds are formed from various primary metabolite biosynthesis processes. This research was a descriptive non-experimental research carried out in three stages. First, search and select articles based on inclusion and exclusion criteria. Second, extraction and synthesis of selected articles. Third, writing results and drawing conclusions. The results of the phytochemical isolation study on various parts of the bitter plant showed that bitter contains dominant secondary metabolites, namely the terpenoid group, especially diterpenoid lactones (andrographolide compounds and their derivatives) and the flavonoid group. These secondary metabolite compounds can be developed as marker compounds and can be used as specific quality parameters for bitter plants. This is very necessary for the process of developing new drugs.

Keywords: Phytochemistry, Andrographis paniculata, Diterpenoid, Flavonoid

Topic: Pharmaceutical sciences