NANOPARTICLES OF MORINGA OLEIFERA LEAF EXTRACT ON ENDOTHELIN 1, sFlt 1 AND BLOOD PRESSURE IN PREGNANT WOMEN WITH HYPERTENSION
Dina Indrati Dyah Sulistyowati (a) , Mardiyono MNS, PhD (b)

(a),(b) Departement of Nursing Poltekkes Kemenkes Semarang

Abstract

Background:
Hypertensive Pregnancy Disorders are one of the causes of increasing morbidity rates and maternal, fetal, and neonatal mortality rates. Management of hypertension in pregnancy can be done pharmacologically and nonpharmacological. Non pharmacological therapies, which can be used to reduce hypertension, and herbal therapies from Moringa leaves processed with nanoparticle technology sFlt 1 and Endothelin 1 are accurate predictors of preeclampsia.

Purpose: this study is to prove that nanoparticles of Moringa Oleifera extract endothelin 1, sFlt 1 levels, and blood pressure in pregnant women with hypertension

Methods: True experiment, Randomized Control Trial with pretest posttest control group design, in two groups, namely the nanoparticle group of Moringa Oleifera extract 500 mg per day during one month and the control group. We investigated 40 people respondents who were pregnant women with hypertension. Endothelin 1, sFlt 1 was measured in serum samples.

Results: As many as 40 pregnant women with hypertension showed an average age of 28.60 until 31.20 years, from the results of the study, showed that in treatment groups before and after the intervention there was a significant difference (p=0.001). Nanoparticles of Moringa Oleifera extract can decrease systolic (p=0.007), and diastole (p=0.045), it reduced sFlt 1 levels (p=0.006), endothelin 1 levels (p=0.000).

Conclusion: Nanoparticles of Moringa Oleifera extract 500 mg per day, have a significant effect on reducing levels of blood pressure, sFlt 1 and endothelin 1 levels in pregnant women with hypertension.

Keywords: nanoparticles of Moringa Oleifera leaf extract, sFlt 1, endothelin 1, blood pressure, pregnant women, hypertension.

Topic: Maternal and child health