Kynurenine/Tryptophan Ratio As Promised Metabolomic Biomarker in Tuberculosis Infection
Fitri Fadhilah (a*) , Agnes Rengga Indrati (b,c), Sumartini Dewi (d) & Prayudi Santoso (e)

a)Doctorate in Medicine Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.
*fitrifadhilahssimkes[at]gmail.com
b)TB Working Group, Infectious Disease Research Center, Faculty of Medicine, Universitas Padjadjaran, Jl. Prof Eykman, No. 38 Bandung 40161, Indonesia
c)Department of Clinical Pathology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Jl Pasteur No. 38 Bandung 40161, Indonesia
d)Immunology Study Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia
Division of Rheumatology, Department of Internal Medicine, Hasan Sadikin General Hospital, Bandung, Indonesia
e)Respirology and Critical Illness Division, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran / Dr. Hasan Sadikin General Hospital, Bandung, Indonesia

Abstract

Immunology and the metabolic system have always been viewed as distinct disciplines. Recent advances in the understanding of immune functions under normal and disease conditions, have linked these disciplines to complex systems. Metabolomics, which is defined as the comprehensive evaluation of small molecule intermediates of metabolism within a biological system that collectively form the metabolome, has developed into an efficient method for discovering potential disruptions of metabolic homeostasis caused by disease. Recently, a prognostic metabolic biomarker with sufficient predictive power for tuberculosis progression has been developed. Targeted research of tryptophan in tuberculosis disease suggests such declines may also replicate induction of indoleamine 2,3-dioxygenase (IDO), the rate-limiting host enzyme for catabolism of tryptophan to kynurenine, which is highly upregulated in the lungs of tuberculosis disease patients. Although the latest diagnostic methods using tuberculosis nucleic acid amplification and interferon &#947- release assay have improved tuberculosis diagnosis, the lack of a biomarker for diagnosing active tuberculosis disease inhibits tuberculosis control. We hope that through this paper the reader can understand the benefits of metabolomics examination, especially as a type of examination that can be used to diagnose and monitor the effect of therapy in tuberculosis patients

Keywords: infection- metabolomic- kynurenine- tryptophan- tuberculosis

Topic: Bioteknologi